TY  - JOUR
T1  - ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE
TT  - AMİTRİPTİLİNİN FAREDEKİ ANTİDEPRESAN BENZERİ ETKİSİNİN ADENOZİN A2A RESEPTÖR ANTAGONİZMASI İLE ARTIŞI
AU  - Sezer, Gülay
PY  - 2018
DA  - December
JF  - Sağlık Bilimleri Dergisi
JO  - JHS
PB  - Erciyes Üniversitesi
WT  - DergiPark
SN  - 1018-3655
SP  - 205
EP  - 210
VL  - 27
IS  - 3
LA  - en
AB  - Objective: The role of the endogenous adenosinergicsystem in the peripheral effect of an antidepressantdrug, amitriptyline, has been demonstrated in painmodels and also in cardiovascular toxicity induced byamitriptyline. We performed this study as there is noinformation on whether adenosine or adenosine A2Areceptor antagonists have any effect on theantidepressant-like activity of amitriptyline in mice.Methods: Balb-c mice were used in experiments andforced swimming test was used to evaluate theantidepressant-like activity. Mice were injected withsaline (control), amitriptyline, SCH 58261 (A2A receptorantagonist), SCH 58261 + amitriptyline, adenosine,adenosine + amitriptyline, intraperitoneally.Results: Amitriptyline decreased immobility timecompared to control group at both doses. SCH 58261did not produce antidepressant like effect in the applieddose alone. Pretreatment of amitriptyline with SCH58261 produced stronger inhibition of immobility timethan amitriptyline induced alone in the same dose. Coadministration of adenosine with amitriptyine,however, it was not decreased the anti-immobility effectof amitriptyline. However, it was not statisticallysignificant.Conclusion: It has been demonstrated thatadenosinergic system may have a role in theantidepressant-like activity of amitriptyline in mice, andpretreatment with the A2A receptor antagonist mayinduce a more pronounced antidepressant-like activity.We are of the opinion that this finding may be ofparticular importance in the case of drug resistantpatients. 
KW  - Amitriptyline
KW  - adenosine
KW  - adenosine A2A receptor
KW  - antidepressan activity
KW  - mouse
N2  - Amaç: Antidepresan bir ilaç olan amitriptilininperiferal etkilerinde adenozinerjik sistemin rolü olduğuağrı modellerinde ve amitriptilinin neden olduğukardiyovasküler sistem toksisitesinde gösterilmiştir.Ancak amitripitilinin antidepresan aktivitesindeadenozin ya da adenozin A2A reseptör antagonismasınınrolü olup olmadığına dair bilgi bulunmadığı için bu çalışmayı planladık.Metod: Deneylerde antidepresan benzeri etkiyi tayiniçin Balb-c fareler üzerinde zorunlu yüzme testi uygulanmıştır. Farelere serum fizyolojik (kontrol grubu),amitriptilin, SCH 58261 (A2A reseptör antagonisti), SCH58261+amitriptilin, adenozin, adenozin+amitriptilinintraperitoneal yoldan uygulanmıştır.Bulgular: Amitriptilin her iki dozunda da kontrol grubuna göre hareketsiz kalma zamanını azaltmıştır.Amitriptilinin hareketsiz kalma süresini azaltıcı etkisiSCH 58261 ile ön muamele edildiğinde daha da artmıştır. Adenozin ile amitriptilin birlikte uygulandığında iseamitriptilinin hareketsiz kalma süresini azaltıcı etkisiazalmakla birlikte bu etki istatistiksel olarak anlamlıbulunmamıştır.Tartışma: Amitriptilinin faredeki antidepresan benzerietkisinde adenozinerjik sistemin rolü olabileceği ve A2Areceptor antagonisti ile ön muamele edildiğinde buetkinin artabileceği gösterilmiştir. Bu bulgunun özellikle ilaca dirençli hastalarda önemli olabileceğini düşünmekteyiz.
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