@article{article_510969, title={High Serum Osmolality May Predict the Disease Severity in Patients with Acute Ulcerative Colitis}, journal={Online Turkish Journal of Health Sciences}, volume={5}, pages={324–329}, year={2020}, DOI={10.26453/otjhs.510969}, author={Vural, Abdussamed and Vural, Aslı and Vural, Selahattin and Turfan, Selim and Dülger, Ahmet Cumhur}, keywords={Akut ülseratif kolit,serum ozmolalitesi,Truelove Witt’s skoru}, abstract={<p> </p> <div style="text-align:justify;"> <span style="font-size:14px;">Objective: Ulcerative colitis (UC) is characterised by chronic immun- mediated inflammation of the colonic mucosa. The Truelove and Witts (TW) criteria have been used to define the severity of the UC. Otherhand, a simplier and unified laboratory tool is needed for better definition of high risk patients with UC. The aim of the study, especially in emergency service applications, was to determine the usefulness of serum osmalality as a biomarker which can easily and rapidly predict the severity of the disease, in which the patient will be advised to be hospitalized after the symptomatic treatment.  </span> </div> <div style="text-align:justify;"> <span style="font-size:14px;">Materials and Methods: In this single-center, retrospective cohort study, we collected data of 62 hospitalized patients with UC such as demographic characteristics and blood sample results evaluated by clinicians. Truelove and Witts (TW) scores of the patients along with serum osmolality were calculated. Stata 14.0. package program was used for data analysis. P <0.05 was considered statistically significant.  </span> </div> <div style="text-align:justify;"> <span style="font-size:14px;">Results: According to our results, patients with hyperosmolality were more likely to have severe UC as defined by having higher scores of TW criteria at baseline. </span> </div> <div style="text-align:justify;"> <span style="font-size:14px;">Conclusion: As a conclusion, serum osmolality can be considered as an useful predictor to demonstrate the severity of the disease. </span> </div>}, number={2}, publisher={Oğuz KARABAY}