@article{article_513113, title={Early Effects of Breast Cancer Chemotherapy by Fluorouracil, Epirubicin and Cyclophosphamide with or without Docetaxel Regimen on the Right and Left Ventricle Functions}, journal={Journal of Human Rhythm}, volume={1}, pages={6–12}, year={2015}, author={Bilir, Cemil and Engin, Hüseyin and Karabag, Turgut and Demirtas, Derya and Demirtas, Orhan}, keywords={Kemoterapi,FEC-Docetaxel rejimi,Ekokardiografi,TAPSE,tei index}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:200%;">Objectives: to investigate global cardiac functional status during adjuvant chemotherapy with Fluorouracil, Epirubicin and <br />Cyclophosphamide (FEC) and FEC-Docetaxel protocol for breast cancer. <br />Material and Method: 51 women treated with adjuvant chemotherapy for breast cancer at the oncology department. <br />Results: LVEF decreased from baseline values of 66%±3 to 64.5%±4.4, p=0.001 at six month calculations as compared to <br />the beginning. There was increase in the Left Ventricular MPI values from the baseline records of 0.45±0.1 to 0.58±0.15, <br />p=0.0001 at six months follow-up. Mean TAPSE values were 2.45±0.42 and 2.05±0.35 cm respectively, p=0.0001. There <br />was increase in the right ventricular TDI MPI values after the therapy as compared to the baseline calculations (0.23 and <br />0.37, p=0.0001) at six months. When we compare the delta values of LEVF, LV MPI, TAPSE and RV TDI MPI in group <br />of FEC alone and FEC followed by Docetaxel regimen, we did not fi nd any signifi cant changes before and after the <br />chemotherapy (p= 0.08, p=0.38, p=0.43 and p=0.2, respectively). <br />Conclusion: Chemotherapy with FEC is associated with subclinical right and left ventricular dysfunction as assessed <br />by TAPSE, left ventricular Doppler myocardial performance index, and right ventricular tissue Doppler myocardial <br />performance index.  <br /> </p>}, number={1}, publisher={Ramazan AKDEMİR}