TY  - JOUR
T1  - A RESEARCH FOR SOME OXAZOLIDINONES TO EVALUATE THEIR ANTIMICROBIAL ACTIVITY
TT  - YENİ OKSAZOLİDİNONLARIN ANTİMİKROBİYAL AKTİVİTELERİNİ DEĞERLENDİREN BİR ARAŞTIRMA
AU  - Kus, Canan
AU  - Ugurlu, Ezgi
AU  - Altanlar, Nurten
PY  - 2018
DA  - September
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - J. Fac. Pharm. Ankara
PB  - Ankara Üniversitesi
WT  - DergiPark
SN  - 1015-3918
SP  - 32
EP  - 37
VL  - 42
IS  - 3
LA  - en
AB  - Objectives: In this research, antimicrobial activity of some new oxazolidinone derivatives were evaluated against S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, methicillin-resistant Staphylococcus aureus (MRSA) clinical isolate and C. albicans ATCC 10231.Material and Method: Formerly obtained and published 10 oxazolidinones were tested against antimicrobial activity and this evaluation was carried out in Mueller-Hinton broth and Sabouraud dextrose broth.Result and Discussion: Compounds E5, and E9 showed antimicrobial activity against both bacteria and fungi with 25 μg/mL and 50 μg/mL, respectively. Our present research and the others have shown that the electro-negativity degree is very important for the biological activity.
KW  - antimicrobial activity
KW  - linezolid
KW  - oxazolidinon
N2  - Amaç: Bu çalışmada, bazı yeni oksazolidinon türevlerinin antimikrobiyal etkileri S. aureus ATCC 25923, E. coli ATCC 25922, B. subtilis ATCC 6633, metisilin-dirençli Staphylococcus aureus (MRSA) klinik izolatı ve C. albicans ATCC 10231’e karşı incelenmiştir.Gereç ve Yöntem: Daha önce elde edilen ve yayınlanan 10 oksazolidinonların antimikrobiyal aktivitesi test edilmiştir ve çalışma Mueller-Hinton broth ve Sabouraud dekstroz broth içinde gerçekleştirilmiştir.Sonuç ve Tartışma: E5 ve E9 bileşikleri, sırasıyla, 25 μg/mL ve 50 μg/mL ile hem bakteri hem de mantarlara karşı antimikrobiyal aktivite göstermiştir. Bizim bu araştırmamız ve diğer bazı çalışmalar, elektro-negatiflik derecesinin biyolojik aktivite için çok önemli olduğunu göstermiştir.
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UR  - https://dergipark.org.tr/tr/pub/jfpanu/issue//514572
L1  - https://dergipark.org.tr/tr/download/article-file/629212
ER  -