TY  - JOUR
TT  - THE RELATIONSHIP BETWEEN SIDE EFFECTS OF THEOPHYLLINE IN COPD PATIENTS WITH PATIENT AGE AND BLOOD ELECTROLYTES
AU  - Yılmaz, Ahmet
AU  - Sezgi, Cengizhan
AU  - Yılmaz, Hatice
AU  - Tanrıverdi, Halis
PY  - 2011
DA  - October
JF  - İzmir Göğüs Hastanesi Dergisi
JO  - İzmir Göğüs Dergisi
PB  - İzmir Göğüs Hastalıkları Hastanesi
WT  - DergiPark
SN  - 1300-4115
SP  - 81
EP  - 87
VL  - 25
IS  - 2
KW  - Teofilin
KW  - Kan elektrolit düzeyleri
KW  - KOAH
N2  - Methylxanthine group drugs are used widely due to become cheap and no patient drug compliance problem such as inhaled medications. The most important limitating reasons their uses are having less branchodilator effects than other bronchodilators, small therapeutic blood levels interval and frequently interacts with other drugs. In this study, we analyzed the kinds and frequency of theophylline-related side effects, due to the many interactions with other drugs in the COPD and asthma patients' recieving intravenous and oral theophylline  For this aim, relationship between the serum levels of theophylline and Na, K, Ca, Cl, glucose was investigated Total 44 COPD and asthma patients were subjected to study.  The average age of patients was 61±5. Serum theophylline Na, K, Ca, Cl and glucose levels were measured for all patients. ECG's of patients were evaluated. The side effects were recorded during the therapy. Tremor in 6 patients, tachycardia in 4 patients, epigastric burning/pain in the stomach in 3 patients were observed. Serum theophylline values in tremor developed patients was about 16,1µg/ml, in taschicardia developed patients was about 14,5 µg/ml, in epigastric burning/pain developed patients was about 9.25 µg/ml. Theophylline derived side effects was not observed in Cor pulmonale patients. Serum theophylline levels did not affects serum Na, K, Ca, Cl and glucose levels and life-threatening side-effects did not observed in applied dose.  As a result, side effects of theophylline can ocur even if used in the recommended therapeutic blood levels. we found that these effects are especially more pronounced in elderly patients. Therefore, theophylline user patients should carefully monitored clinically beside of the monitoring plasma theophylline levels during theophylline administration.
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CR  - Dicle Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları, DİYARBAKIR
CR  - e-posta: drahmet_007@yahoo.com
UR  - https://dergipark.org.tr/tr/pub/ighd/issue//522417
L1  - https://dergipark.org.tr/tr/download/article-file/641882
ER  -