TY  - JOUR
TT  - IS THERE RELATIONSHIP BETWEEN ERCC1 EXPRESSION LEVEL AND RESPONSE TO TREATMENT AND PROGNOSIS IN ADVANCED STAGE LUNG CANCER TREATED WITH CISPLATIN-BASED CHEMOTHERAPY?
AU  - Yılmaz, Ufuk
AU  - Polat, Gülru
AU  - Dinç, Zekiye Aydoğdu
AU  - Kömürcüoğlu, Berna
PY  - 2012
DA  - May
JF  - İzmir Göğüs Hastanesi Dergisi
JO  - İzmir Göğüs Dergisi
PB  - İzmir Göğüs Hastalıkları Hastanesi
WT  - DergiPark
SN  - 1300-4115
SP  - 13
EP  - 19
VL  - 26
IS  - 1
KW  - Sisplatin
KW  - metastatik
KW  - akciğer kanseri
KW  - tedavi
KW  - ERCC1
N2  - It is important to know the tumor resistance against cisplatin before the treatment of nonsmall cell lung cancer (NSCLC). The purpose of this study was to evaluate the response to treatment and survival in patients with NSCLC treated with cisplatin-based chemotherapy according to ERCC1 Expression.  Among 119 patients treated with cisplatin and vinorelbine or docetaxel, 39 (32%) patients enrolled who have enough tumor tissue to analyse ERCC1 expression. ERCC1 expression defined as negative in score 0-1, positive in score 2-3.  There was no difference between ERCC1 positive and negative groups (p:0.63). Mean survival was 14.7 month (95% CI; 10.0-19.3 month) in ERCC1 negative group , 10.9 month (95% CI; 7.4-14.3 month) in ERCC1 positive group(p:0.23). Progression free survival was 7.9 month in ERCC1 negative group (95% CI;5.8-9.9 month), 6.2 month in ERCC1 positive group (95% CI;4.0- 8.5 month)(p:0.27).  In conclusion; to identify ERCC1 expression level of tumor tissues in NSCLC patients before treatment was not usefull in prediction of treatment response and prognosis.
CR  - cisplatin based adjuvant chemotherapy. N Engl J Med 2006; 355: 983-91.
CR  - Azuma K, Komohara Y, Sasada T, Terazaki Y, Ikeda J, Hoshino T, et al. Excision repair cross-complementation group 1 predicts progression free and overall survival in nonsmall cell lung cancer patients treated with platinum-based chemotherapy. Cancer Sci 2007; 98: 1336-43.
CR  - Dabholkar M, Vionnet J, Bostick-Burton F, Yu JJ, Reed E. Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum based chemotherapy. J Clin Invest 1994; 94: 703-8.
CR  - Park DJ, Lenz HJ. Determinants of chemo- sensitivityin gastric cancer. Curr Opin Pharmacol ; 6: 337-44. Shirota Y, Stoehlmacher J, Brabender J, Xiong YP, Uetake H, Danenberg KD, et al. ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy. J Clin Oncol 2001; 19: 4298
CR  - ERCC1 in nonsmall cell lung cancer and Vilmar AC, Santoni-Rugiu E, Sorensen JB. ERCC1 and histopathology in advanced NSCLC patients randomized in a large multicenter phase III trial. Ann Oncol 2010; 21: 1817-24.
CR  - Cobo M, Isla D, Massuti B, Montes A, et al. Customizing cisplatin based on quantitative excision repair cross-complementing 1 mRNA expression: A phase III trial in non- small-cell lung cancer. J Clin Oncol 2007; :(19): 2747-54. non-small cell lung cancer. J Thorac Oncol ; 2(10): 902-6.
CR  - Wachters FM, Wong LS, Timens W, Kampinga HH, et al. ERCC1, hRad51, and BRCA1 protein expression in relation to tumour response and survival of stage III/IV NSCLC patients treated with chemotherapy. Lung Cancer ; 50(2): 211-9. Lee HW, Choi YW, Han JH, Kim JH, et al. Expression of excision repair cross-comp- lementation group 1 protein predicts poor outcome in advanced non-small cell lung cancer patients treated with platinum-based doublet chemotherapy. Lung Cancer 2009; (3): 377-82. Yazıflma Adresi: Dr. Gülru POLAT
CR  - Dr. Suat Seren Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Arafltırma Hastanesi, Göğüs Hastalıkları, İZMİR e-posta : gulruerbay@yahoo.com
UR  - https://dergipark.org.tr/tr/pub/ighd/issue//522581
L1  - https://dergipark.org.tr/tr/download/article-file/642113
ER  -