TY  - JOUR
TT  - WARFARIN-INDUCED LEUKOCYTOCLASTIC VASCULITIS AND SCIN NECROSIS
AU  - Bulcun, Emel
AU  - Ekici, Aydanur
AU  - Ekici, Mehmet
AU  - Karabulut, Ayşe Anil
AU  - Cerit, Ahu
PY  - 2016
DA  - October
JF  - İzmir Göğüs Hastanesi Dergisi
JO  - İzmir Göğüs Dergisi
PB  - İzmir Göğüs Hastalıkları Hastanesi
WT  - DergiPark
SN  - 1300-4115
SP  - 133
EP  - 136
VL  - 30
IS  - 2
KW  - Warfarin
KW  - lökositoklastik vaskülit
N2  - Oral anticoagulants are commonly used to prevent  and treat venous and arterial embolism.Warfarin  induced skin reactions include tissue necrosis and  leukocytoclastic vasculitis (LV). Warfarin-induced  LV case is presented here. 61 years old male  patient. He has been followed-up for the diagnosis  of chronic obstructive pulmonary disease (COPD),  cardiac failure. He had been diagnosed as  pulmonary embolism and started to use warfarin 5  months ago and admitted to hospital with the  complaints of progressive dyspnea, cough, and  phlegm in the last 2 weeks. According to the  physical examination, he had sporadic  maculopapular rash. Maculopapular rash increased  in his feet during follow-up, and edema developed.  After a while, necrosis signs in lower extremities  and maculopapular rash in his back were  occurred. Main diagnosis was considered as  warfarin-induced skin necrosis, and coumadin was  ceased. Low molecular weight heparine treatment  was initiated. According to skin biopsy, it was  compatible with LV. Colchicine, prednol 40 mg  were initiated. Significant lesion improvement was  observed on the bilateral legs and back of the  patient. In conclusion, New skin signs should be  evaluated carefully and potential side effects  should be considered in the patients on warfarin.
CR  - 1. Gallerani M, Manfredini R, Moratelli S. Nonhaemorrhagic
adverse reactions of oral
anticoagulant therapy. Int J Cardiol 1995; 49:1-
7.
CR  - 2. Sallah S, Thomas DP, Roberts HR. Warfarin and
heparin-induced skin necrosis and the purple
toe syndrome: infrequent complications of
anticoagulant treatment. Thromb Haemost
1997; 78: 785-90.
CR  - 3. Essex DW, Wynn SS, Jin DK. Late-onset
warfarin-induced skin necrosis: case report and
review of the literature. Am J Hematol 1998;
57: 233-7.
CR  - 4. Despoina D. Kakagia, Nikolaos Papanas,
Efthimios Karadimas, and Alexandros
Polychronidis Warfarin-Induced Skin Necrosis
Ann Dermatol 2014; 26: 96-8.
CR  - 5. Roujeau JC, Stern RS. Severe adverse
cutaneous reactions to drugs. N Engl J Med
1994; 331: 1272-85.
CR  - 6. Kurt M, Shorbagi A, Aksu S, Haznedaroglu I,
Altundag K, Erkin G. Warfarin-induced skin
necrosis and leukocytoclastic vasculitis in a
patient with acquired protein C and protein S
deficiency. Blood Coagul Fibrinolysis 2007; 18:
805-6.
CR  - 7. Chien-Yi Hsu, Wei-Sheng Chen, Shih-Hsien
Sung. Warfarin-induced Leukocytoclastic
Vasculitis: A Case Report and Review of
Literature. Intern Med 2012; 51: 601-6.
CR  - 8. Calabrese LH, Michel BA, Bloch DA, et al. The
American College of Rheumatology 1990
criteria for the classification of hypersensitivity
vasculitis. Arthritis Rheum 1990; 33:1108-13.
CR  - 9. Fiorentino DF. Cutaneous vasculitis. J Am Acad
Dermatol 2003; 48: 311-40.
CR  - 10. Bircher AJ, Scherer K. Delayed cutaneous
manifestations of drug hypersensitivity. Med
Clin North Am 2010; 94: 711-25.
CR  - 11. Tanay A, Yust I, Brenner S, Koffler M, Abramov
AL. Dermal vasculitis due to coumadin
hypersensitivity. Dermatologica 1982; 16: 178-
85.
CR  - 12. Yaghoubian B, Ngo B, Mak M, Ostrzega E,
Tesoro J, Mitani GH. Warfarin-induced leukocytoclastic
vasculitis. Cutis 2005; 75: 329-38.
CR  - 13. Chen KR, Carlson JA. Clinical approach to
cutaneous vasculitis. Am J Clin Dermatol 2008;
9: 71-92.
CR  - 14. Holder SM, Joy MS, Falk RJ. Cutaneous and
systemic manifestations of drug-induced
vasculitis. Ann Pharmacother 2002; 36: 130-47.
UR  - https://dergipark.org.tr/tr/pub/ighd/issue//523238
L1  - https://dergipark.org.tr/tr/download/article-file/643047
ER  -