TY - JOUR T1 - Effectiveness of light emitting diode phototherapy for direct coombs positive newborns TT - Direkt coombs pozitif yenidoğanlarda light emitting diode fototerapinin etkinliği AU - Okur, Nilüfer AU - Büyüktiryaki, Mehmet AU - Uras, Nurdan AU - Öncel, Mehmet Yekta AU - Ertekin, Ömer AU - Canpolat, Fuat Emre AU - Oğuz, Şerife Suna PY - 2019 DA - August Y2 - 2019 DO - 10.35440/hutfd.525717 JF - Harran Üniversitesi Tıp Fakültesi Dergisi PB - Harran Üniversitesi WT - DergiPark SN - 1304-9623 SP - 169 EP - 173 VL - 16 IS - 2 LA - en AB - Background: Phototherapyis the most frequently used treatment when serum bilirubin levels exceedphysiological limits. The direct antiglobulin titer (DAT) test is regarded asthe cornerstone of diagnosis of immune hemolytic disease of the newborn. Methods: Patients withhyperbilirubinemia who were born in our hospital and whose gestational age wasover 35 weeks were enrolled. DAT positive and DAT negative patients werecompared in terms of light emitting diode (LED) phototherapy efficacy. Results: Seventy-sevencases were DAT-negative and 72 were DAT-positive. No statistically significantdifferences were found for the duration of phototherapy and hospitalizationbetween the DAT-positive and negative groups. In the DAT-positive group, thephototherapy needs of the patients were determined to occur at an earlier stage(postnatal age 1.4 day, p<0.05), and the rate of patients requiring exchangetransfusion, blood transfusion and intravenous immunoglobulin was found to bestatistically significant higher in DAT-positive infants.Conclusions: Although LEDphototherapy is effective in DAT-positive patients, the need for exchange transfusion and intravenözimmunoglobulin (IVIG) shows that thereis still a need for more effective phototherapy in these patients. KW - Direct antiglobulin KW - hyperbilirubinemia KW - newborn KW - phototherapy N2 - Amaç: Fototerapi, serumbilirubin düzeyleri fizyolojik sınırları aştığında en sık kullanılan tedaviyöntemidir. Direkt antiglobulin titresi (DAT) testi yenidoğanın immün hemolitikhastalığı tanısının temel taşı olarak kabul edilir.Materyal ve Metot: Hastanemizde doğan vegebelik yaşı 35 haftadan fazla olan hiperbilirubinemili hastalar çalışmayaalındı. DAT pozitif ve DAT negatif hastalar light emitting diode (LED)fototerapi etkinliği açısından karşılaştırıldı.Bulgular: Yetmiş yedi olgu DATnegatif, 72 olgu DAT pozitif idi. DAT pozitif ve negatif gruplar arasındafototerapi ve hastanede yatış süresi açısından istatistiksel olarak anlamlı birfark bulunmadı. DAT pozitif grupta hastaların fototerapi gereksinimlerinin dahaerken bir aşamada (doğum sonrası yaş 1.4 gün, p <0.05) olduğu tespit edildi,exchange transfüzyon ve intravenöz immunoglobulin (IVIG) gerektiren hastalarınoranı DAT pozitif bebeklerde istatistiksel olarak anlamlı derecede yüksekti.Sonuç: LED fototerapi DATpozitif hastalarda etkilidir ancak kan değişimi ihtiyacı ve IVIG bu hastalardahala daha etkili fototerapiye ihtiyaç olduğunu göstermektedir. CR - 1. Murray NA, Roberts IA. Haemolytic disease of the newborn. Arch Dis Child Fetal Neonatal Ed 2007;92:F83–88 CR - 2. Madan A, Huntsinger K, Burgos A, Benitz WE. Readmission for newborn jaundice: the value of the Coomb’s test in predicting the need for phototherapy. Clin. Pediatr 2004;43: 63–8 CR - 3. Ozolek JA, Watchko JF, Mimouni F. Prevalence and lack of clinical significance of blood group incompatibility in mothers with blood type A or B. J Pediatr 1994;125:87–91 CR - 4. Meberg A, Johansen KB. 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