@article{article_530721, title={Antioxidant and anticholinesterase activities of Heliotropium dolosum, H. lasiocarpum and H. hirsutissimum growing in Turkey}, journal={Erzincan University Journal of Science and Technology}, volume={12}, pages={1381–1391}, year={2019}, DOI={10.18185/erzifbed.530721}, author={Karakaya, Songül and Koca, Mehmet and Kılıç, Ceyda Sibel}, keywords={Antioksidan,Antikolinesteraz}, abstract={<p class="MsoNormal" style="margin-bottom:12pt;text-align:justify;line-height:115%;"> <span lang="en-us" style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Alzheimer’s
disease (AD) has encouraged science to find plants or biologic compounds which
can be utilized for prophylaxis of AD. <i>Heliotropium </i>
genus is presented by 16 taxa in Turkey and they contain pyrrolizidine
alkaloids, and certain are known to have antioxidant and anticholinesterase
activities. The paper displays the anticholinesterase and antioxidant
capacities of the aerial parts lyophilized aqueous extracts of  <i>H.
dolosum, H. lasiocarpum  </i>and <i> H. hirsutissimum. </i> Phenolic
contents and antioxidant activity of examples were determined by
Folin-Ciocalteu’s, qualitative/quantitative DPPH and TBA. Anticholinesterase
activity was assessed by Ellman’s method. The total phenolic content of <i>H. lasiocarpum </i> extract was found the
highest (738.39 mg/g), however the total phenolic content of <i>H. dolosum </i> extract was found the lowest
(122.731 mg/g). Every example indicated that antioxidant activity with DPPH
test and <i>H. lasiocarpum </i> presented the
highest activities (69.99 μg/mL). Furthermore, the <i>H. lasiocarpum </i> extract indicated considerable inhibition towards
acetylcholinesterase (5.90%) and butyrylcholinesyterase (24.04%) enzymes. These
findings suggest that these <i>Heliotropium </i> species can be effective for
pharmaceutic products that achieve anticholinesterase and antioxidant
activities. </span> <br /> </p> <p> </p>}, number={3}, publisher={Erzincan Binali Yıldırım Üniversitesi}