@article{article_533166, title={MICROWAVE-ASSISTED SYNTHESIS OF SOME NEW DERIVATIVES OF 4-SUBSTITUTED-3-(MORPHOLINOMETHYL)-4H-1,2,4- TRIAZOLE-5-THIOLES}, journal={Journal of Faculty of Pharmacy of Ankara University}, volume={43}, pages={220–229}, year={2019}, DOI={10.33483/jfpau.533166}, author={Shcherbyna, Roman}, keywords={1.2.4-triazol, mikrodalga sentezi, heterosiklik}, abstract={<p class="Pa8" style="text-align:justify;line-height:115%;"> <b> <i> <span style="font-size:10pt;line-height:115%;background:#FFFFFF;"> <span>        </span> </span> </i> </b> <b> <span style="font-size:10pt;line-height:115%;background:#FFFFFF;">Objective: </span> </b> <i> <span style="font-size:10pt;line-height:115%;background:#FFFFFF;"> </span> </i> <i> <span style="font-size:10pt;line-height:115%;">The purpose of this work is to synthesize new series
of 4-((5-((cyclohexylmethyl)thio)-4-R <sub>1 </sub>-4H-1,2,4-triazol-3-yl)methyl)morpholines
and 4-((4-R <sub>1 </sub>-5-(pyridin-2-ylthio)-4H-1,2,4-triazol-3-yl)methyl)morpholines
using a microwave synthesis system. </span> </i> </p> <p> <i> </i> </p> <i> </i> <p class="Pa8" style="text-align:justify;line-height:115%;"> <b> <i> <span style="font-size:10pt;line-height:115%;"> <span>        </span> </span> </i> </b> <b> <span style="font-size:10pt;line-height:115%;">Material and Method: </span> </b> <i> <span style="font-size:10pt;line-height:115%;"> </span> </i> <i> <span style="font-size:10pt;line-height:115%;">As starting compounds are used 4-R <sub>1 </sub>-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles
(where, R <sub>1 </sub>=H, methyl, ethyl, phenyl, amino). Synthesis was carried
out using a microwave synthesis system Milestone Flexi Wave. The structure of
synthesized compounds is confirmed by the use of modern methods of analysis <sup>1 </sup>H
NMR, <sup>13 </sup>C NMR spectroscopy, elemental analysis and gas
chromatography–mass spectrometry (GS/MS). </span> </i> <i> <span lang="tr" style="font-size:10pt;line-height:115%;" xml:lang="tr"> </span> </i> </p> <p> <i> </i> </p> <i> </i> <p class="MsoNormal" style="text-align:justify;text-indent:35.4pt;line-height:150%;"> </p> <p class="MsoNormal" style="text-align:justify;line-height:115%;"> <b> <span style="font-size:10pt;line-height:115%;"> <span>         </span>Result and Discussion: </span> </b> <i> <span style="font-size:10pt;line-height:115%;"> <span>As a result of the conducted
experiment, the synthesis method is optimized for
4-((5-((cyclohexylmethyl)thio)-4-R <sub>1 </sub>-4H-1,2,4-triazol-3-yl)methyl)morpholines
and 4-((4-R <sub>1 </sub>-5-(pyridin-2-ylthio)-4H-1,2,4-triazol-3-yl)methyl)morpholines
by microwave irradiation. It was established that the reactions proceed to the
end in all described conditions, but the reaction with the parameters t=10 min,
T=160 <sup>о </sup>С is the most technologically optimal. This approach has
allowed reducing energy costs and increasing the yield of target
compounds. <span>  </span>As a result, a class of new
derivatives of 1,2,4-triazole has been obtained, which can be used in further
pharmacological studies as valuable biological agents. </span> </span> </i> </p> <p> <i> </i> </p> <i> </i> <p> <i> </i> </p> <i> </i>}, number={3}, publisher={Ankara Üniversitesi}