@article{article_535602, title={The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty}, journal={Çağdaş Tıp Dergisi}, volume={9}, pages={9–14}, year={2019}, DOI={10.16899/gopctd.535602}, author={Bozkaya, Davut and Ergenekon, Ebru and Yucel, Aysegul and Ozdek, Sengul and Hirfanoglu, İbrahim and Turan, Ozden and Turkyilmaz, Canan and Onal, Esra and Koc, Esin and Atalay, Yıldız}, keywords={Retinopathy of prematurity,IGF-1,IGFBP-3}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span lang="tr" style="font-size:10pt;line-height:200%;font-family:Arial, sans-serif;" xml:lang="tr">Introduction:
Most important factors in retinopathy of prematurity (ROP) are prematurity and
oxygen toxicity although blood transfusions, insulin like growth factor-1 (
IGF-1), insulin like growth factor binding protein 3 (IGFBP-3) and vascular
endothelial growth factor (VEGF) also have important roles. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span lang="tr" style="font-size:10pt;line-height:200%;font-family:Arial, sans-serif;" xml:lang="tr">The
objectives of this study were, to measure IGF-1 and IGFBP-3 levels in preterm
newborns before and after blood transfusion and assess if the effect of
transfusion in development of ROP is via these mediators, and to investigate
whether IGF-1 and IGFBP-3 levels measured at 32 and 33 gestational age (GA)
were different in preterm newborns with and without ROP. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span lang="tr" style="font-size:10pt;line-height:200%;font-family:Arial, sans-serif;" xml:lang="tr">Material
and Methods: Preterm newborns with gestational age ≤34 weeks were included and
blood samples were obtained before and after red blood cell (RBC) transfusion. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span lang="tr" style="font-size:10pt;line-height:200%;font-family:Arial, sans-serif;" xml:lang="tr">Results:
Thirty newborns were included, 17 of whom had ROP ( stage 1: n=11, stage 2:
n=5, stage 3: n=1). IGF-1 and IGFBP-3 levels did not change after RBC
tranfusion. Excluding the patient with stage 3 ROP all ROP patients were
referred as mild ROP. No difference was observed between IGF-1 and IGFBP-3
levels of the patients with and without mild ROP. Patients with mild ROP had
significantly more number of transfusions. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span lang="tr" style="font-size:10pt;line-height:200%;font-family:Arial, sans-serif;" xml:lang="tr">Conclusions:
Erythrocyte transfusion increased the frequency of ROP, whereas IGFBP-3 and
IGF-1 were not associated of ROP. </span> </p> <p> </p>}, number={1}, publisher={Rabia YILMAZ}