@article{article_538024, title={Protective effects of hesperidin on ionizing radiation-induced liver damage}, journal={Turkish Journal of Clinics and Laboratory}, volume={10}, pages={498–504}, year={2019}, DOI={10.18663/tjcl.538024}, url={https://izlik.org/JA64SC57NN}, author={Aydın, Bengü Gülhan and Pişkin, Özcan and Baş, Yılmaz and Karakaya, Kemal and Elmas, Özlem and Can, Murat and Büyükuysal, Çağatay}, keywords={Hesperidin,karaciğer hasarı,oksidatif stres}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr">Aim: </span> </b> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr">Liver
is mostly exposed to radiation during radiotherapy to the upper abdomen, the
right lobe of the lung, distal esophagus tumors or total body irradiation.
Radiation may lead to cellular damage, and clinical and laboratory findings of
liver dysfunction. This study aimed <b> </b>to
investigate the protective effect of peroral hesperidin on reducing oxidative
stress in liver tissue  caused by
ionızing radiation <b> </b> </span> </p> <p> <b> </b> </p> <b> </b> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr">Material and Methods: </span> </b> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr">24
adult male rats were randomly divide into four groups <b>. </b> </span> <span lang="en-gb" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb"> Group control
was given only physiological saline, Group HES was given hesperidin at 50 mg/kg
body weight (BW) for 15 days, Group RAD was given only irradiation, and Group
HES+RAD was given hesperidin at 50 mg/kg BW daily and then irradiated. At the
end of 15 </span> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr">hesperidinin </span> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr"> </span> <span lang="en-gb" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-gb">days,
the animals in Groups RAD and HES+RAD were exposed to a dose of 10 Gy to the
abdominopelvic region. Liver and blood samples were used for determination of total
antioxidant status (TAS) and malondialdehyde (MDA) and also histopathological
examination was performed. </span> <b> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr"> </span> </b> </p> <p> <b> </b> </p> <b> </b> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr">Results: </span> </b> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr">Compared
with the Group RAD, the plasma and tissue MAD level was significantly decreased
in Group HES+RAD (p=0.002). Both plasma and tissue levels of TAS was found
significantly higher in HES+RAD group (respectively, p=0.002,p=0.004). Histological
examination of Group RAD, portal edema, significant intra-cytoplasmic
vacuolization, swelling in the hepatocytes, necrosis, significant sinusoidal and
 central vein dilation and congestion
were observed . In group HES+RAD periportal edema, central vein dilation and
congestion were not histologically evident when compared with Group RAD. </span> </p> <p> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr">Conclusion: </span> </b> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr">Radiotherapy was found to lead to an increase in lipid
peroxidation and a reduction in anti-oxidant capacity; 50 mg/kg/day hesperidin
administration for 15 consecutive days was seen to reduce the histological
changes of liver damage and oxidative stress in rats  </span> <b> <span lang="tr" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="tr"> </span> </b> </p> <p> <b> </b> </p> <b> </b>}, number={4}