TY  - JOUR
T1  - Akut Koroner Sendrom ile Başvuran Hastalarda Asetil Salisilik Asit Direncinin Araştırılması
TT  - Investigation of acetylsalicylic acid resistance in patients with acute coronary syndrome
AU  - Aksoy, Fatih
AU  - Baş, Hasan Aydın
AU  - Bağcı, Ali
AU  - Varol, Ercan
AU  - Altınbaş, Ahmet
PY  - 2019
DA  - June
DO  - 10.22312/sdusbed.539426
JF  - Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi
PB  - Süleyman Demirel Üniversitesi
WT  - DergiPark
SN  - 2146-247X
SP  - 167
EP  - 171
VL  - 10
IS  - 2
LA  - tr
AB  - Giriş ve amaç:Akut koroner sendrom (AKS) ile başvuran ve/veya stent uygulanan hastalardaklopidogrel ve aspirin tedavisi günümüzde standart tedavidir. Bununla beraberklopidogrel tedavisine yanıtsızlık olumsuz sonuçlarla ilişkili olması nedeniile günümüzde önemli bir sorundur. Antitrombositer ilaçların etkinliğini ölçmekiçin kullanılan trombosit fonksiyon testleri çoğu kez pahalı, zaman alıcı veulaşılması zor testlerdir. Aspirin ve klopidogrel direncini saptamak içinpratik, kolay uygulanabilinir, ucuz ve güvenilir parametrelere ihtiyaç vardır. Metot: AkutKoroner Sendrom tanısı ile klopidogrel ve aspirin kullanan 531 hasta çalışmayaalındı. Alınan kan örneklerinde MEA (multiple electrod aggregometry) ileçalışıldı. Sonuçlar eğri altında kalan alan (AUC) cinsiden verildi. AUC>500olması aspirin direnci olarak yorumlandı. Bulgular: Toplamda 45 (%8,5) hastada ise aspirin direncisaptandı. Aspirin direnci için isediyabet, hiperlipidemi, ürik asit düzeyi, LDL kolesterol düzeyi, non-HDLkolesterol düzeyi, kalsiyum düzeyi, trombosit sayısı, risk faktörü olaraktespit edildi. Sonuç: Bu çalışma;Diyabet, hiperlipidemi, LDL kolesterol düzeyi, non-HDL kolesterol düzeyi,kalsiyum düzeyi, trombosit sayısı, aspirin direncini ön görmedekullanılabilecek bir parametre olduğunu gösterdi.
KW  - Aspirin direnci
KW  - akut koroner sendrom
KW  - risk faktörleri
N2  - Background: Aspirin and clopidogrel therapy is the standardof care in patients with acute coronary syndrome (ACS) and stent implantation.However, Clopidogrel and aspirin resistance are arising increasingly. As thisnonresponsiveness is associated with increased adverse outcome, detection ofthese subjects in daily practice is important in order to withhold a more aggressivetherapy and closer follow up. The platelet function tests for measurementaspirin and clopidogrel resistance are very expensive and time consuming. Weneed have practically, easily accessible, cheaper and reliable parameters fordetecting aspirin and clopidogrel resistanceMethods: A total of 541 patients who had been onclopidogrel and aspirin therapy for the diagnosis of acute coronary syndromewere enrolled in this study. Aspirin resistance was analyzed by MultiplateMP-0120 device by using the method of whole blood aggregometry. The amount ofADP induced platelet aggregation was assessed as area under curve (AUC), and acut off value of 500 for aspirin resistance, above which the patient isconsidered as aspirin resistant, was used. Results: Amongthe 541 patients analyzed, 45 were found aspirin nonresponder (8.5%). DiabetesMellitus, Hyperlipidemia, calcium levels, platelet levels, were predictoryfactor for aspirin resistance.Conclusion: This study showed that diabetes mellitus,hyperlipidemia, calcium levels, platelet levels are associated with aspirin resistanceespecially in patients with ACS.
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UR  - https://doi.org/10.22312/sdusbed.539426
L1  - http://dergipark.org.tr/tr/download/article-file/737199
ER  -