TY - JOUR T1 - Helicobacter pilori eradikasyonu için verilen iki farklı ardışık tedavinin eradikasyon oranlarının karşılaştırılması TT - Comparison ratios of two different sequential treatments for Helicobacter pylori eradication AU - Gönderen, Aysun AU - Gönderen, Kamil AU - Yıldız, Mehmet PY - 2019 DA - July JF - Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi PB - Sağlık Bakanlığı Ankara Eğitim ve Araştırma Hastanesi WT - DergiPark SN - 1304-6187 SP - 138 EP - 144 VL - 52 IS - 2 LA - tr AB - Amaç: Helicobacter Pylori (HP) peptikülser, gastrik kanser ile ilişkisi iyi bilinen gram (-) mikroaerofilikbakteridir. Bundan dolayı infekte hastalarda HP eradikasyon tedavisiönerilmektedir. Bu çalışmada da iki farklı eradikasyon tedavisinin etkinliğininkarşılaştırılması amaçlandı. Materyal veMetod: Şubat 2009 – Mayıs 2010 tarihleri arasında Dışkapı Yıldırım BeyazıtEğitim Araştırma Hastanesi Gastroenteroloji ve Dahiliye polikliniklerine reflü,bulantı-kusma ve gastrik ağrı şikayetleri ile başvurup endoskopi yapılan veendoskopik olarak gastrik ülser, duodenal ülser veya gastrit tanısı konulan,immüno-histokimyal olarak HP pozitif saptanan ve daha önce eradikasyon tedavisialmamış 98 hasta çalışmaya dahil edildi. Hastalar randomize olarak iki grubaayrıldı ve ilk gruba bir hafta omeprazol ve amoksisilin ikinci hafta omeprazolve metronidazol verildi. Diğer gruba ilk 7 gün omeprazol ve amoksisilin ikincihafta omeprazol, metronidazol ve tetrasiklin verildi. Tedavi bitiminden sonraeradikasyon oranını belirlemek için kontrol endoskopileri yapılarak biyopsilerialındı. Bulgular: Çalışmaya alınanhastaların 47’si (%56) kadın ve 46’sı (%54,7) 40 yaş altındaydı. Birinci rejimtedaviyi alan hastalarda tedavi başarısı tüm hasta grubuna bakıldığında %32.4,ikinci rejim tedaviyi alan hastalarda tedavi başarısı %59.6 olarak saptandı veiki grup tedavi rejimi arasında istatistiksel olarak anlamlı fark vardı. Sonuç: Tetrasiklin içeren tedavigrubunda eradikasyon başarı oranı sayısal olarak daha yüksek ve istatistikselolarak anlamlı olmakla beraber eradikasyon oranları genel literatüre göre %80altında ve düşük bulunmuştur. Bu sonuç başta antibiyotik direnci olmak üzeretedavinin başarısını azaltabilecek nedenlerin ortaya konması gerektiğini ve HPeradikasyonunda alternatif tedavilere ihtiyaç olduğunu göstermektedir. KW - Helikobakter pilori KW - peptik ülser KW - tedavi N2 - Purpose: Helicobacter Pylori(HP) is a gram (-) microaerophilic bacterium that related with peptic ulcer andgastric cancer. The aim of this study was to compare the efficacy of the twodifferent eradication therapies. Materialand Methods: 98 patients were included in the study who was admitted toGastroenterology and Internal Medicine outpatient clinics of Dışkapı YıldırımBeyazıt Training and Research Hospital with complaints of reflux, nausea,vomiting or gastric pain and had detected HP positive immunohistochemically alsohad not received any eradication treatment before. The patients were randomlydivided into two groups. The first groupwas treated with omeprazole and amoxicillin in the first week then withomeprazole and metronidazole in the second week. The second group was treatedwith omeprazole and amoxicillin in the first week and then with omeprazole,metronidazole and tetracycline in the second week. After the treatment, controlendoscopy was performed and the biopsies were taken to determine theeradication ratios. Results: Theeradication ratio of treatment in the first group was 32.4% and 59.6% in thesecond group. 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