@article{article_543107, title={Antioxidant Characteristic of Prophylactic Hypericum Perforatum Oil Administration in a Rabbit Model of Palatal Mucosal Injury}, journal={Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi}, volume={7}, pages={55–64}, year={2020}, DOI={10.34087/cbusbed.543107}, author={Günpınar, Şadiye and Alperat Kılıç, Olgu and Tosun, Mehmet and Fırat, Tülin}, keywords={Katalaz,hypericum perforatum yağı,malondialdehit,zeytinyağı,yara iyileşmesi}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:150%;"> <b> <u> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">Objective: </span> </u> </b> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;"> </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">This study was aimed to
determine the antioxidant and soft tissue wound healing properties of
prophylactic (p) application of topical <i>Hypericum
perforatum </i> </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;"> ( </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">HP)
oil in rabbits. <b> </b> </span> </p> <p> <b> </b> </p> <b> </b> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:150%;"> <b> <u> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">Materials
and Methods: </span> </u> </b> <b> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;"> </span> </b> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">Thirty-six
New Zealand albino rabbits were randomly classified as p-HP oil (test, <i> n </i> = 18) and p-olive oil (control, <i> n </i> = 18) groups. Each groups of rabbits
were topically pretreated with either HP or olive oil before the surgery. </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;color:#191919;" xml:lang="en-us">Gingival biopsies were excised and
analyzed for re- </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">epithelialization (RE) and granulation
tissue maturation (GTM) and </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;color:#191919;" xml:lang="en-us">clinical appearance were scored for erythema, epithelial confluence and
general wound appearance on days 3, 7 and 14 after surgery. </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">L </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;color:#191919;" xml:lang="en-us">evels of </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">VEGF and FGF-2
were assessed </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;color:#191919;" xml:lang="en-us">
immunohistochemically. </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">T </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;color:#191919;" xml:lang="en-us">issue catalase (CAT) and malondialdehyde
(MDA) levels </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;"> were measured using
ELISA. </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;color:#191919;"> </span> <b> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;"> </span> </b> </p> <p> <b> </b> </p> <b> </b> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:150%;"> <b> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">Results: </span> </b> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;color:#191919;" xml:lang="en-us"> Higher epithelial confluence ( </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">on
the 7 <sup>th </sup> day </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;color:#191919;" xml:lang="en-us">) and general wound appearance scores ( </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">on the 7 <sup>th </sup>and
14 <sup>th </sup>days </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;color:#191919;" xml:lang="en-us">)
were determined in </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">p-HP oil than that of p-olive oil group </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">(p<0.05) </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">. On the other hand RE
scores did not differ between groups </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">(p>0.05) </span> <span style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;">. The number of positively stained FGF-2
cells were higher in the test than that of control </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">(p<0.05) </span> <span style=}, number={1}, publisher={Manisa Celal Bayar Üniversitesi}