@article{article_549371, title={Therapeutic potential of morus nigra on 5-fluorouracil-induced gastrointestinal mucositis in rats}, journal={Osmangazi Tıp Dergisi}, volume={42}, pages={363–372}, year={2020}, DOI={10.20515/otd.549371}, author={Yiğitaslan, Semra and Özkaraman, Ayşe and Açıkgöz, Ayfer and Balcı Alparslan, Güler and Toprak, Çiğdem and Göger, Fatih and Sahin, Erhan}, keywords={Mukozit,Sıçan,Morus nigra,5-florourasil}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:normal;"> <span lang="en-gb" style="font-size:10pt;" xml:lang="en-gb">To investigate
the therapeutic potential of <i>Morus Nigra </i>
on the mucositis of digestive system induced via 5-fluorouracil in rats. A total
of 26 rats were divided into 4 groups as control (C), mucositis (M), <i>Morus nigra </i> extract-1(MN-1) and <i>Morus nigra </i> extract-2 (MN-2). Mucositis
was induced by intraperitoneal injection of 60 mg/kg 5-fluorouracil (5-FU). The
antioxidant enzyme levels in blood samples were analysed by ELISA. Histological
analysis and immunohistochemical staining for NF-kB and TNF-α were done. Increased
oxidative markers were found in mucositis group and increased antioxidative status
was found in MN-1 and MN-2 groups. All histochemical analyses suggested that
5-FU causes intestinal degeneration; the MN-1 extract reduced this degeneration
but did not completely treat it. The therapeutic potential of MN-2 extract was
lower than the MN-1. Results of the present study suggest that, though partly,
MN-1 extract in particular may have biochemically and histologically positive
effects against experimental mucositis induced by 5-FU in rats. </span> </p> <p> </p> <p> </p>}, number={4}, publisher={Eskişehir Osmangazi Üniversitesi}