TY  - JOUR
TT  - Gender-Dependent Differences on Spatial Learning Performance in Hypothyroid Rats
AU  - Babur, Ercan
AU  - Tan, Burak
AU  - Yıldız, Nesrin
AU  - Batakçı, Melek
AU  - Süer, Cem
AU  - Dursun, Nurcan
PY  - 2017
DA  - December
JF  - Sağlık Bilimleri Dergisi
PB  - Erciyes Üniversitesi
WT  - DergiPark
SN  - 1018-3655
SP  - 233
EP  - 239
VL  - 26
IS  - 3
KW  - Hipotiroidizm
KW  - Sıçan
KW  - Öğrenme
KW  - Bellek
KW  - Morris Su Tankı
N2  - The aim of the study was to investigate the effects of experimental hypothyroidism (HT) on spatial learning and memory disorders to establish relationship with gender. Propylthiouracil (PTU) was used to induce HT (0.2 mg / kg, 21 days with drinking water). Morris Water Tank test (MWTT) was used to evaluate learning and memory changes. When the anxiety level was expressed as the rate of tigmotaxis in the MWVT, it was found that the HT group was less anxious than the control group and there was no significant difference between the Group*Sex interaction. The swimming speed (SS) of female groups was found to be slower than the male groups. In evaluating the learning performance, the mean distance to platform (MdtoP), distance movement (DM) and escape latency (EL) was evaluated. During EL and DM assessment, the HT state prolonged the time to find the platform and increased swimming distance. However, the gender factor did not affect the deterioration of the HT state. Evaluating the MdtoP, which is not affected by SS, the learning performance in female was significantly reduced (p<0,001) and the HT state did not affect this decrease. In addition, hypothyroid status alone increased the mean distance to platform. According to the Post Hoc Tukey test, HT groups were realized that it spent less time than the control groups in target quadrant (p<0,05). However, the gender factor did not affect this significance. As a result, we found that the animals with hypothyroidism had poor learning and memory performance, and gender difference did not affect this deterioration in hypothyroidism.
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UR  - https://dergipark.org.tr/tr/pub/eujhs/article/553094
L1  - https://dergipark.org.tr/tr/download/article-file/693931
ER  -