TY  - JOUR
T1  - İndirekt Hiperbilirubinemili Hastalarda Kranial Manyetik Rezonans Görüntüleme Bulguları
TT  - Cranial Magnetic Resonance Imaging Findings in Patients with Indirect Hyperbilirubinemia
AU  - Ulu, Esra Meltem Kayahan
AU  - Karadeli, Elif
AU  - Dönmez, Fuldem Yıldırım
AU  - Altun, Erdem
AU  - Durukan, Elif
AU  - Erkek, Nilgün
PY  - 2012
DA  - September
JF  - Cukurova Medical Journal
JO  - Cukurova Med J
PB  - Çukurova Üniversitesi
WT  - DergiPark
SN  - 2602-3032
SP  - 139
EP  - 145
VL  - 37
IS  - 3
LA  - tr
AB  - Amaç: İndirekt hiperbiluribinemili hastalarda manyetik rezonans görüntüleme (MRG) değişikliklerinin sıklığını tanımlamak.  Yöntem: Biz indirek hiperbiluribinemili 18 yenidoğanın MRG bulgularını sunduk. Üç grup arasındaki biokimyasal, klinik ve görüntülemedeki farkları istatistiksel olarak değerlendirdik.    Bulgular: Pik bilirubin seviyeleri 5 yenidoğanda (grup 1)  20- 24 mg/dl, 6 yenidoğanda (grup 2) 25- 29 mg/dl ve 7 yenidoğanda (grup 3) 30 mg/dl ve daha yüksekti. Üç grup arasında hastaların MRG bulguları ve nörolojik bulguları arasında istatistiksel olarak önemli fark vardı.   Sonuç: Biz kernikteruslu hastalarda MRG değişiklikleri bulduk. Nörolojik muayeneleri normal olmasına rağmen hiperbilirubinemili hastalarda öncelikle T1A görüntülerde değişiklikler saptadık. Beyinde bilirubinin toksik etkilerinin anlaşabilmesi için klinik takiple birlikte büyük çalışmalar gerekmektedir.
KW  - Manyetik Rezonans Görüntüleme
KW  - Kernikterus
KW  - Neonatal Hiperbiluribinemi
N2  - Abstract  Purpose: To describe the magnetic resonance imaging (MRI) changes in the patients with indirect hyperbilirubinemia.   Methods: MRI findings of eighteen neonates with indirect hyperbilirubinemia were reported by us. The differences in imaging, clinical and biochemical data between three groups were  evaluated  statistically.   Results: Peak bilirubin levels were between 20 and 24 mg per deciliter in 5 of the newborns (group 1), 25 and 29 mg per deciliter in 6 of the newborns (group 2) and 30 mg per deciliter or more in 7 newborns (group 3). There was statistically significant difference between the neurological findings and MRI findings of the patients between three groups.   Conclusion: We always demonstrated MRI changes in the patients with kernicterus. Firstly,  T1 weighted changes were described in patients with hyperbilirubinemia despite normal neurological examinations. Larger studies with clinical follow up are needed for further understanding of toxic effect of bilirubin in brain.     Key words:     Özet
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UR  - https://dergipark.org.tr/tr/pub/cumj/article/55364
L1  - https://dergipark.org.tr/tr/download/article-file/47358
ER  -