TY  - JOUR
T1  - ANTIBACTERIAL EFFECT OF SOME 3 -IMINO-4-SUBSTITUTED-1,2,5- THIADIAZOLIDINE 1,1-DIOXIDES
TT  - Bazı 3-imino-4-sübstitüe-1,2,5-tiroidyazolidin 1,1-dioksitlerin antibakteriyel etkisi
AU  - Çil, Elif
AU  - Börçek Kasurka, Ceren
AU  - Gediz Erturk, Aliye
AU  - Kontaş, Seval
PY  - 2020
DA  - July
DO  - 10.18036/estubtdc.561008
JF  - Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi - C Yaşam Bilimleri Ve Biyoteknoloji
JO  - Estuscience - Life
PB  - Eskişehir Teknik Üniversitesi
WT  - DergiPark
SN  - 2667-4203
SP  - 255
EP  - 264
VL  - 9
IS  - 2
LA  - en
AB  - Organosulfur compound's functionality constitutes an essential class of therapeutic agents in current medicinal chemistry. Especially sulfonamides called sulfa drugs were performed as both chemotherapeutic agents and useful antibacterial derivatives developed for medicine. The sulfamides in the same family with the sulfonamides have similar biological activities. In our research, it was studied with some 3-imino-4-substituted-1, 2, 5-thiadiazolidine 1,1-dioxides (ISTDs- 4a-d, four samples) that are five-membered cyclosulfamides. These compounds were previously synthesized and structurally characterized. The goals of this study are to investigate minimum inhibition concentration (MIC) values and antibacterial effects of these ISTDs compounds on Bacillus subtilis NRRL B-209T, Escherichia coli ATCC®25922T, Micrococcus luteusNRRL B-1018T, Nocardia abscessus DSM 44432T, Nocardia cyriacigeorgica DSMZ 44484T, Pseudomonas aeruginosa NRRL B-2679T Staphylococcus aureus ATCC®6538T, Streptomyces murinus ISP 5091T.
KW  - Nocardia
KW  - sulfonamides
KW  - microdilution MIC
KW  - MBC
N2  - Organosülfür bileşiklerinin işlevselliği, mevcut tıbbikimyada önemli bir terapötik madde sınıfını oluşturur. Özellikle sülfa ilaçlaradı verilen sülfonamitler hem kemoterapötik ajanlar hem de tıp içingeliştirilen etkili antibakteriyel türevler olarak gerçekleştirilmiştir.Sülfonamidlerle aynı ailedeki sülfamitler benzer biyolojik aktiviteleresahiptir. Araştırmamızda, beş üyeli siklosülfamitler olan bazı 3-imino-4-ikameedilmiş-1,2,5-tiadiazolidin 1,1-dioksitler (ISTD'ler-4a-d, dört örnek) ileçalışılmıştır. Bu bileşikler daha önce sentezlenmiş ve yapısal olarakkarakterize edilmiştir. Bu çalışmanın amacı, Minimum inhibisyon konsantrasyon(MİK) değerlerini ve bu ISTD bileşiklerinin antibakteriyel etkilerini Bacillussubtilis NRRL B-209, Escherichia coli ATCC®25922, Micrococcus luteus NRRLB-1018, Nocardia abscessus DSM 44432, Nocardia cyriacigeorgica DSMZ 44484,Pseudomonas aeruginosa NRRL B-2679 Staphylococcus aureus ATCC®6538,Streptomyces murinus ISP 5091 üzerinde araştırmaktır.
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UR  - https://doi.org/10.18036/estubtdc.561008
L1  - https://dergipark.org.tr/tr/download/article-file/708657
ER  -