@article{article_568226, title={Investigation of the positive effects of silymarin on valproic acid-induced liver damage in rats}, journal={Adıyaman Üniversitesi Sağlık Bilimleri Dergisi}, volume={5}, pages={1445–1458}, year={2019}, DOI={10.30569/adiyamansaglik.568226}, author={Aktaş, İbrahim and Armağan, İlkay}, keywords={Valproroik asit,silmarin,karaciğer,sıçan}, abstract={<p class="MsoNormal" style="margin-right:3.35pt;text-align:justify;line-height:115%;"> <b> <span style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;">Purpose: </span> </b> <span style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;color:#333333;letter-spacing:.1pt;background:#FCFCFC;">In this study, we
evaluated the potential hepatoprotective effects of silymarin on valproic
acid-induced liver injury by histological and biochemical parameters in rat
liver. </span> </p> <p> </p> <p class="MsoNormal" style="margin-right:3.35pt;text-align:justify;line-height:115%;"> <b> <span style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;">Method: </span> </b> <span style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;color:#333333;letter-spacing:.1pt;background:#FCFCFC;">Experimental procedures
were performed on 21 male Sprague Dawley rats. Rats were divided into three
groups: group 1, control; group 2, valproic acid; group 3, valproic acid +
silymarin. The groups were administered 500 mg/kg/day valproic acidand 100
mg/kg/daysilymarin for 14 days, except control group. </span> </p> <p> </p> <p class="MsoNormal" style="margin-right:3.35pt;text-align:justify;line-height:115%;"> <b> <span style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;">Results: </span> </b> <span style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;color:#333333;letter-spacing:.1pt;background:#FCFCFC;">Silymarin treatment decreased
the levels of serumgamma glutamyl transferase, alanine amino transferase, aspartate
aminotransferase and increreased serum albumin levelssignificantly (p
<0.05). In addition, increased amount of malondialdehyde and decreased
levels of glutathione with valproic acid were significantly suppressed by
silymarin in liver tissue (p <0.05). The combination of silymarinwith valproic
acid reduced loss of body weight in the present study. Histologically, the
extent of liver damage was significantly lower in the valproic acid+silymarin
group (p<0.005). Oxidative stress was decreased, antioxidant activity was
increased and histopathological changes were reduced in the valproic acid + silymarin
group compared to the valproic acid group. </span> </p> <p> </p> <p> </p> <p class="MsoNormal" style="margin-right:3.35pt;text-align:justify;line-height:115%;"> <b> <span style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;">Conclusion: </span> </b> <span style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;color:#333333;letter-spacing:.1pt;background:#FCFCFC;">This study revealed that
the liver injury induced by valproic acid was attenuated with silymarin
administration. Silymarincan protect rat liver against valproic acid induced
injury by its anti-oxidative </span> <span style="font-size:10pt;line-height:115%;font-family:’Times New Roman’, serif;letter-spacing:.1pt;background:#FCFCFC;">effect,
and might be useful for reducing the severity of liver injury. </span> </p> <p> </p>}, number={2}, publisher={Adıyaman Üniversitesi}