TY  - JOUR
T1  - Seroprevalence of Cytomegaloviruses in Afghanistan
AU  - Husseini, Abbas Ali
AU  - Fidan, İsil
AU  - Saeed, Khwaja Mir İslam
AU  - Bozdayı, A. Mithat
PY  - 2019
DA  - June
DO  - 10.5799/jmid.574566
JF  - Journal of Microbiology and Infectious Diseases
JO  - J Microbil Infect Dis
PB  - Aydın ECE
WT  - DergiPark
SN  - 2146-3158
SP  - 78
EP  - 82
VL  - 09
IS  - 02
LA  - en
AB  - ABSTRACTObjective: Human Cytomegalovirus (CMV) is a member of the Herpesviridaefamily, with the ability to establish a long-lived latent infection. CMV infectioncauses problems in immunocompromised hosts undergoing organ and stem celltransplantation. The prevalence of CMV in adults varies in different geographicregions. The purpose of this study was to assess the prevalence of CMV in theadult population of Afghanistan, which did not have epidemiologic informationfor CMV infection.Methods: Atotal of 500 adults residing in main regional provinces of Afghanistanincluding Nangarhar, Herat, Mazar-i Sharif, Kandahar and Kabul in the age rangeof 25-70 years old were randomly selected to include in the study. Among theparticipants, 263 (52.6%) were female and 237 (47.4%) were male. The sampleswere tested for the presence of CMV IgM and IgG antibodies usingchemiluminescence immunoassay on the Abbott Architect automated platform.Results:Theseropositivity of CMV was found 99.79 % in Afghanistan. There were no significantdifferences in the prevalence CMV infection among the five regions. Theseropositivity anti-CMV IgG positive rate in Kandahar, Kabul, Nangarhar and,Herat was determined as 100%.  The CMVIgG prevalence was 98.99% in Mazar-i Sharif. Anti CMV IgM was found 1.24% inAfghanistan.Conclusions: Our study shown thatthe seroprevalence is high in Afghanistan. Because of the high frequency ofseropositivity in general population in Afghanistan, the approaches forpreventing CMV reactivation need to be developed.  JMicrobiol Infect Dis 2019; 9(2): 78-82.
KW  - Seroprevalence
KW  - CMV
KW  - adult
KW  - population
KW  - Afghanistan
CR  - ABSTRACT
Objective: Human Cytomegalovirus (CMV) is a member of the Herpesviridae family, with the ability to establish a long-lived latent infection. CMV infection causes problems in immunocompromised hosts undergoing organ and stem cell transplantation. The prevalence of CMV in adults varies in different geographic regions. The purpose of this study was to assess the prevalence of CMV in the adult population of Afghanistan, which did not have epidemiologic information for CMV infection.
Methods: A total of 500 adults residing in main regional provinces of Afghanistan including Nangarhar, Herat, Mazar-i Sharif, Kandahar and Kabul in the age range of 25-70 years old were randomly selected to include in the study. Among the participants, 263 (52.6%) were female and 237 (47.4%) were male. The samples were tested for the presence of CMV IgM and IgG antibodies using chemiluminescence immunoassay on the Abbott Architect automated platform.
Results: The seropositivity of CMV was found 99.79 % in Afghanistan. There were no significant differences in the prevalence CMV infection among the five regions. The seropositivity anti-CMV IgG positive rate in Kandahar, Kabul, Nangarhar and, Herat was determined as 100%.  The CMV IgG prevalence was 98.99% in Mazar-i Sharif. Anti CMV IgM was found 1.24% in Afghanistan.
Conclusions: Our study shown that the seroprevalence is high in Afghanistan. Because of the high frequency of seropositivity in general population in Afghanistan, the approaches for preventing CMV reactivation need to be developed.  J Microbiol Infect Dis 2019; 9(2): 78-82.
UR  - https://doi.org/10.5799/jmid.574566
L1  - https://dergipark.org.tr/tr/download/article-file/731534
ER  -