@article{article_586538, title={The Investigation of Cell Adhesion Molecules in the Lung Tissues of Cattle with Cystic Echinococcosis}, journal={Etlik Veteriner Mikrobiyoloji Dergisi}, volume={30}, pages={14–19}, year={2019}, DOI={10.35864/evmd.586538}, author={Yavuz, Orhan and Dinçel, Güngör Çağdaş and Gökpınar, Sami and Haydardedeoğlu, Ali Evren}, keywords={CD68,NMNAT 3,Neuregulin 1,Neuregulin 2,Patoloji}, abstract={<p>Cystic echinococcosis is a zoonotic disease with worldwide distribution caused by Echinococcus granulosus,  </p> <p>represents a substantial global health problem. Hydatid cyst (Echinococcus) has a remarkable negative effect on the  </p> <p>health of people and the economic development of the country. The objective of this study was to investigate the CD68,  </p> <p>nicotinamide nucleotide adenylyltransferase 3 (NMNAT 3), Neuregulin 1 (NRG1) and Neuregulin 2 (NRG2) expres- </p> <p>sions in bovine lungs infected with E. granulosus and to identify whether they have any correlation with pulmonary  </p> <p>pathology. For this purpose, 30 bovine lung tissues were used between January 2016 and December 2016 collected in  </p> <p>Kırıkkale  slaughterhouse.  In  histopathologic  examinations,  proliferation  of  fibrous  connective  tissue  and  infiltration  </p> <p>of mononuclear cells were detected in the lung tissues of the bovine. Most of the cysts were seen to be quite thick  </p> <p>capsule. There was also a cellular line rich in abundant fibroblasts and mononuclear cells. The cyst wall was found to  </p> <p>be an eosinophilic laminar structure. There was infiltration with lymphocytes and macrophages, especially eosinophils  </p> <p>and giant cells. Immunohistochemically, CD68 positivity was seen around the bronchi, bronchioles and cystic matter.  </p> <p>However; NMNAT 3, NRG1 and NRG2 showed no positive reactions in macrophages, bronchi, bronchioles and alveo- </p> <p>lar epithelium. These results indicate that NMNAT 3, NRG1 and NRG2 pathways were not used in pulmonary pathol- </p> <p>ogy. Therefore, it is the most important result of the study that the adhesion molecules in pulmonary pathology are not  </p> <p>originating from NMNAT 3, NRG1 and NRG2. </p>}, number={1}, publisher={Veteriner Kontrol Merkez Araştırma Enstitüsü}, organization={Aksaray University Scientific Research Committee}