@article{article_587236, title={Peripheral Analgesic Effect and Possible Mechanisms of Ferulic Acid}, journal={Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi}, volume={9}, pages={385–392}, year={2019}, DOI={10.31020/mutftd.587236}, author={Kaşık, Merve and Eken, Hazal and Arslan, Rana and Bektas, Nurcan}, keywords={Ferulik asit,Nitrik oksit,Guanilat siklaz,KATP kanalları,Ağrı}, abstract={<p class="MsoNormal"> <span style="font-size:9pt;text-align:justify;">Ferulic acid is a bioactive phenolic compound that is
found intensely in plants used in traditional medicine such as </span> <i style="font-size:9pt;text-align:justify;">Ferula </i> <span style="font-size:9pt;text-align:justify;"> </span> <i style="font-size:9pt;text-align:justify;">assa-foetida L. </i> <span style="font-size:9pt;text-align:justify;">. The analgesic effect of various medicinal plants
has been associated with its constituent, ferulic acid. However, there are
limited number of studies about mechanism of its analgesic action. The aim of
this study was to evaluate the contribution of NO/cGMP/PKG/K </span> <sub style="text-align:justify;">ATP </sub> <span style="font-size:9pt;text-align:justify;">
pathway in peripheral analgesic effect of ferulic acid by acetic acid-induced
(0.6 % acetic acid, </span> <i style="font-size:9pt;text-align:justify;">i.p </i> <span style="font-size:9pt;text-align:justify;">.) writhing
test in mice. For this purpose, following the determination of the analgesic
effect of ferulic acid at the doses of 20, 40, 80 and 160 mg/kg ( </span> <i style="font-size:9pt;text-align:justify;">p.o. </i> <span style="font-size:9pt;text-align:justify;">), NO precursor 100 mg/kg L-arginine
( </span> <i style="font-size:9pt;text-align:justify;">i.p </i> <span style="font-size:9pt;text-align:justify;">.), nitric oxide synthase
inhibitor 30 mg/kg L-NAME ( </span> <i style="font-size:9pt;text-align:justify;">i.p </i> <span style="font-size:9pt;text-align:justify;">.),
guanylate cyclase inhibitor 20 mg/kg methylene blue ( </span> <i style="font-size:9pt;text-align:justify;">i.p. </i> <span style="font-size:9pt;text-align:justify;">) and K </span> <sub style="text-align:justify;">ATP </sub> <span style="font-size:9pt;text-align:justify;"> channel blocker 10 mg/kg glibenclamide ( </span> <i style="font-size:9pt;text-align:justify;">i.p. </i> <span style="font-size:9pt;text-align:justify;">) were administered separately prior
to ferulic acid treatment at the dose effective for clarifying the mechanism of
action. Reduction in the number of writhes was evaluated as peripheral
analgesic activity. Ferulic acid significantly decreased the number of writhes
at the doses of 40, 80 and 160 mg/kg. 80 mg/kg ferulic acid and 100 mg/kg
acetyl salicylic acid demonstrated similar efficacy. L-arginine and methylene
blue relatively reversed the reduction in the number of writhes caused by
ferulic acid at 80 mg/kg, whereas L-NAME did not. Glibenclamide pre-treatment
significantly inhibited analgesic effect induced by ferulic acid. The results
of the study indicate that ferulic acid has peripheral analgesic activity and
it is mediated predominantly by activation of K </span> <sub style="text-align:justify;">ATP </sub> <span style="font-size:9pt;text-align:justify;"> channels and
partially by cGMP. In conclusion, findings of this study demonstrate that
ferulic acid may provide an advantage in K </span> <sub style="text-align:justify;">ATP </sub> <span style="font-size:9pt;text-align:justify;"> channel-targeted
management of pain. </span> <br /> </p> <p> <b> </b> </p> <b> </b> <span style="background-color:rgb(255,255,255);"> </span> <span lang="en-us" style="font-size:11pt;line-height:150%;font-family:Calibri, sans-serif;background-color:rgb(255,255,255);" xml:lang="en-us"> </span> <p> </p>}, number={3}, publisher={Mersin Üniversitesi}, organization={Anadolu University}