@article{article_589071, title={Template Synthesis, Characterization, Antioxidant Effects, DNA Cleavage and Antimicrobial Studies of ZnII, NiII, MnII, CuII and CoII Complexes Containing Pyridazinone Moiety}, journal={Adıyaman University Journal of Science}, volume={10}, pages={40–54}, year={2020}, DOI={10.37094/adyujsci.589071}, author={Sönmez, Mehmet and Bakırcı, Özlem and Soğukömeroğulları, Hatice Gamze and Özdemir, Sadin and Yalçın, Mustafa Serkan}, keywords={Template sentez, Schiff baz kompleks, Antioksidan aktivite, DNA bölünmesi, Antimikrobiyal aktivite}, abstract={<p class="MsoNormal" style="text-align:justify;text-indent:36pt;line-height:200%;"> <span lang="en-us" xml:lang="en-us"> <span style="font-size:12px;">In this study, novel
five Schiff base metal complexes derived from Zn </span> <sup> <span style="font-size:12px;">II </span> </sup> <span style="font-size:12px;">, Ni </span> <sup> <span style="font-size:12px;">II </span> </sup> <span style="font-size:12px;">,
Mn </span> <sup> <span style="font-size:12px;">II </span> </sup> <span style="font-size:12px;">, Cu </span> <sup> <span style="font-size:12px;">II </span> </sup> <span style="font-size:12px;"> and Co </span> <sup> <span style="font-size:12px;">II </span> </sup> <span style="font-size:12px;"> metal salts </span> <span style="color:#212121;"> <span style="font-size:12px;">and 5-benzoyl-4-hydroxy-2-methyl-6-phenyl-2H-pyridazine-3-one
with </span> <i> <span style="font-size:12px;">o </span> </i> <span style="font-size:12px;">-aminophenol have been
synthesized using a template method.  </span> </span> </span> <span style="font-size:12px;">Metal complexes were characterized by elemental analysis, FT-IR, UV-Vis, Mass and magnetic susceptibility.   </span> <span style="font-size:12px;">Antioxidant effects, DNA cleavage, and antimicrobial studies of synthesized compounds were performed. DPPH scavenging and metal chelating activity was found to increase with concentration. The highest DPPH activity and ferrous ion chelating activity were obtained from compound Zn. DNA cleavage studies indicated that all tested compounds were cleavage active at the concentration of 100 mg/L. While all the synthesized compounds displayed antibacterial activity against E. hirae in order of Mn>Zn=Ni=Co>Cu. The compound Ni only showed antimicrobial activity against all microorganisms tested, especially against L. pneumophila subsp. pneumophila with inhibition zone value equal to 13 mm. </span> </p> <p> </p>}, number={1}, publisher={Adıyaman Üniversitesi}, organization={Gaziantep University}