TY  - JOUR
T1  - Güneydoğu Anadolu Bölgesi jüvenil idiyopatik artrit hastalarında alt tip dağılımı ve üveit sıklığı
TT  - Subtype distribution and frequency of uveitis in Southeastern Anatolian children with juvenile idiopathic arthritis
AU  - Çakan, Mustafa
AU  - Öztürk, Kübra
PY  - 2020
DA  - January
DO  - 10.16948/zktipb.590889
JF  - Zeynep Kamil Tıp Bülteni
PB  - Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH
WT  - DergiPark
SN  - 1300-7971
SP  - 27
EP  - 30
VL  - 51
IS  - 1
LA  - tr
AB  - Amaç:Juvenil idiyopatik artrit (JİA) tüm dünyada en sık gözlenen çocukluk çağıromatizmal hastalığıdır. Tek bir hastalık olmayıp alt gruplardan oluşmaktadır.Kas iskelet sistemi dışında üveit şeklinde göz tutulumu önemli bir morbiditenedenidir. Çalışmamızın amacı kliniklerimizde takip edilen JİA hastaların alttip dağılımını ve üveit sıklığını saptamaktır.Metod:Kliniklerimizde JİA tanısı ile takip ve tedavi edilen tüm hastaların dosyalarıgeriye dönük olarak taranmıştır. Bulgular: Çalışmamıza264 JİA hastası dahil edilmiştir. Hastaların %54.9’u kız iken %45.1’i erkek idive ortalama takip süresi 13.8 ± 5.8 ay idi. JİA alt tip dağılımına bakıldığındaen sık oligoartiküler JİA (%42.4) gözlenmekte idi. Entezit ilişkili artrit (%21.6)ikinci sırada iken diğer JİA alt tip dağılımı şu şekilde idi; sistemik JİA(%13.6), romatoid faktör (RF) negatif poliartiküler JİA (%10.2), RF pozitifpoliartiküler JİA (%9.5), psoriatik artrit (%1.9) ve sınıflandırılamayan artrit(%0.8). Üveit toplam 23 hastada (%8.7) gözlenmiş olup üveit hastalarının%91.3’ü oligoartiküler JİA grubunda idi. Sistemik JİA hastalarının %13.8’indemakrofaj aktivasyon sendromu gözlendi. Son kontroldeki hastalık aktivitesinebakıldığında hastaların %18.6’sı aktif iken %81.4’ü remisyonda takipedilmekteydi. Sonuç: Ülkemizdeen sık gözlenen JİA alt tipi diğer ülkelerde olduğu gibi oligoartiküler JİA’dır.Ancak batı ülkelerinden farklı olarak ikinci en sık gözlenen alt tip entezitilişkili artrittir. Ülkemiz JİA hastalarının diğer bir farkı da, JİA ilişkiliüveitin daha az gözlenmesidir. Oligoartiküler JİA üveitin en sık gözlendiği altgruptur. Güncel tedavi seçeneklerinin artması ile hastaların büyük çoğunluğundahastalık remisyonu sağlanabilmektedir.
KW  - juvenile idiopatik artrit
KW  - üveit
N2  - Aim:Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease ofchildhood in the world. It is not a single disease rather composed of distinct subtypes.Apart from musculoskeletal complications, uveitis is one of the major causes ofmorbidity in JIA. The aim of this study was to demonstrate subtype distributionand frequency of uveitis in JIA.Method:The study was conducted in two pediatric rheumatology centers of Southeasternpart of Turkey. Results: Thecohort consisted of 264 children with slightly female predominance (females:54.9%, males: 45.1%). Mean duration of follow-up was 13.8 ± 5.8 months. Themost common subtype was oligoarticular JIA (42.4%) followed by enthesitisrelated arthritis (21.6%). The distribution of other subtypes were as follows;systemic JIA (13.6%), rheumatoid factor (RF) negative polyarticular JIA (10.2%),RF positive polyarticular JIA (9.5%), psoriatic arthritis (1.9%) andunclassified arthritis (0.8%). The frequency of uveitis was 8.7% and 91.3% ofthe patients with uveitis had oligoarticular JIA. Macrophage activationsyndrome was observed in 13.8% of systemic JIA patients. While 18.6% of thepatients had active disease at the time of enrollment, 81.4% had remission. Conclusion:As in other parts of the world, oligoarticular JIA is the most common subtypein our country. But, in contrast to western countries, enthesitis relatedarthritis is the second most common subtype in Turkey. The frequency of uveitisis low in Turkish JIA children that is another major difference from thewestern countries and oligoarticular JIA is the most common subtype associatedwith uveitis. With the introduction of newer treatment modalities, remission isan achievable goal in most of the JIA patients.
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UR  - https://doi.org/10.16948/zktipb.590889
L1  - https://dergipark.org.tr/tr/download/article-file/1022508
ER  -