TY  - JOUR
T1  - PANCREATITIS IN CHILDREN: A SINGLE CENTER EXPERIENCE
TT  - Çocuklarda Pankreatit: Tek Merkez Deneyimi
AU  - Bükülmez, Ayşegül
AU  - Balıkoğlu, Pelin
AU  - Oflu, Ayşe Tolunay
AU  - Özer Gökaslan, Çiğdem
PY  - 2020
DA  - November
DO  - 10.12956/tchd.600267
JF  - Türkiye Çocuk Hastalıkları Dergisi
JO  - Türkiye Çocuk Hast Derg
PB  - T.C. Sağlık Bakanlığı Ankara Şehir Hastanesi
WT  - DergiPark
SN  - 1307-4490
SP  - 522
EP  - 527
VL  - 14
IS  - 6
LA  - en
AB  - Objective: The aim of this study was to evaluate the clinical, laboratoryand etiological differences between children having acute pancreatitis, acuterecurrent pancreatitis and chronic pancreatitis. Method: Medical records of children who were diagnosed withpancreatitis between January 2014 and December 2017 were evaluatedretrospectively. The study was approvedby the Ethics Committee of Afyonkarahisar University of Health Sciences. Our cases were classified as acutepancreatitis, acute recurrent pancreatitis and chronic pancretitis according toINSPPIRE group definitions. Results:Etiology, demographic characteristics, laboratory and radiological findingswere compared between acute pancreatitis (group 1) and acute recurrent andchronic pancreatitis (group 2) groups. 43 patients (78.2%) were enrolled inacute pancreatitis group (group 1). In group 2; 8 cases had acute recurrentpancreatitis and 4 cases had chronic pancreatitis [a total of 12 cases (21.8%)]. the etiologies of our cases were examined; Group 1 had idiopathic (88.5%), stone (2.3%),trauma (2.3%), infections (4.6%) and choledochal cyst (2.3%), respectively. Ingroup 2, they were found to be idiopathic (50%), congenital anomalies of thepancreatic duct (8.3%), allergy (8.3%), autoimmunity (8.3%) and genetic causes(25%). There was no statistical difference between the groups in terms oflaboratory values. In our study, the cause of pancreatitis could not be generallyidentified in all groups. Conclusions:In cases having acute pancreatitis,infections were the second most common etiology; and common causes of acuterecurrent and chronic pancreatitis have been found as genetic causes.
KW  - acute pancreatitis
KW  - acute recurrent pancreatitis
KW  - chronic pancreatitis
KW  - etiology
N2  - Amaç: Bu çalışmada akut pankreatit, akut rekürren pankreatit vekronik pankreatit tanısı ile izlenen çocukların klinik, laboratuvar veetiyolojik farklılıklarının değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Ocak 2014-Aralık 2017 tarihleri arasındapankreatit tanısı ile izlenen çocukların tıbbi kayıtları retrospektif olarakdeğerlendirilmiştir. Çalışmamıza Afyonkarahisar Sağlık Bilimleri ÜniversitesiTıp Fakültesi Etik Kurulu’ndan onay alınmıştır. Olgularımız INSPPIRE grubutanımlamalarına göre akut pankreatit, akut rekürren pankreatit ve kronik pankretitolarak sınıflandırılmıştır. Akut pankreatit (grup 1) ve akut rekürren ve kronikpankreatit (grup 2) grupları arasında etiyoloji, demografik özellikler,laboratuvar ve radyolojik bulgular karşılaştırılmıştır.Bulgular: Akut pankreatit grubunda(grup 1) 43 hasta (%78,2) mevcuttur. Grup 2; akut rekürren pankreatit tanısıalan 8 olgu ve kronik pankreatit tanısı ile izlenen 4 olgu içermektedir [toplam12 olgu (%21,8)]. Olgularımızın etiyolojisine bakıldığında grup 1’de idiyopatik(%88,5), taş(%2,3), travma(%2,3) ve enfeksiyonlar (%4,6),koledok kisti (%2,3);grup 2 de ise idiyopatik (%50), pankreatik kanalın konjenital anomalileri(%8,3), alerji (%8,3), otoimmünite (%8,3) ve genetik sebeplerdir (%25). Her ikigrup arasında laboratuvar değerleri açısından istatistiksel bir farkbulunmamıştır. Sonuç: Çalışmamızda tüm gruplardagenellikle pankreatitin nedeni tanımlanamamıştır. Akut pankreatit olgularındaetiyolojide ikinci sırada enfeksiyonlar mevcut olup, akut rekürren ve kronikpankreatitte sık görülen nedenler genetik sebepler olarak bulunmuştur.
CR  - 1.	Werlin SL, Wilschanski M. Acute pancreatitis. In: Kliegman RM, ed. Nelsons Essentials of Pediatrics. 20th ed. Philadelphia, PA: Saunders/Elsevier; 2016:1913-14. 2.	Morinville, V. D., Lowe, M. E., Ahuja, M., Barth, B., Bellin, M. D., Davis, H., et.al. Design and implementation of INSPPIRE. J Pediatr Gastroenterol Nutr. 2014;59(3):360-364. doi:10.1097/MPG.0000000000000417. 3.	Morinville V.D, Husain S.Z, Bai H, Barth B, Alhosh R, Durie P.R, et al. Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr. 2012;55(3):261-265. doi:10.1097/MPG.0b013e31824f15164. 	Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-184. doi:10.1038/s41575-018-0087-55. 	Poddar U, Yachha SK, Borkar V, Srivastava A, Kumar S. A Report of 320 Cases of Childhood Pancreatitis. Pancreas. 2017;46(1):110-115. doi:10.1097/MPA.00000000000007336. 	Kandula L, Lowe ME. Etiology and Outcome of Acute Pancreatitis in Infants and Toddlers. J Pediatr. 2008;152(1):106-110.e1. doi:10.1016/J.JPEDS.2007.05.0507. 	Pant C, Deshpande A, Olyaee M, Anderson M P, Bitar A, Steele M.I, et al. Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009. Rakonczay Z, ed. PLoS One. 2014;9(5):e95552. doi:10.1371/journal.pone.00955528. 	Ünlüsoy Aksu A, Sarı S, Eğritaş Gürkan Ö, Dalgıç B. Türk çocuklarda pankreatit: tek merkez deneyimi. Cukurova Med J. 2019;44(3):1-1. doi:10.17826/cumj.5116059. 	Alabdulkareem A, Almahmoud T, Al-Tahan H, Javad S, Al Hatlani M. Etiology and clinical characteristics of pediatric acute pancreatitis in Saudi Arabia: a 20-year experience from a single tertiary center. Int J Pediatr Adolesc Med. 2018;5(1):13-17. doi:10.1016/j.ijpam.2018.01.00110. 	Bai HX, Lowe ME, Husain SZ. What have we learned about acute pancreatitis in children? J Pediatr Gastroenterol Nutr. 2011;52(3):262-270. doi:10.1097/MPG.0b013e3182061d7511. 	Taylor C.J, Chen K, Horvath K, Hughes D, Lowe M.E, Mehta D, et al. ESPGHAN and NASPGHAN Report on the Assessment of Exocrine Pancreatic Function and Pancreatitis in Children. 2015. doi:10.1097/MPG.00000000000008312.      Abu-El-Haija M, Kumar S, Quiros J.A, Balakrishnan K, Barth B, Bitton S, et al. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr. 2018; 66(1):159-176. doi:10.1097/MPG.0000000000001715
CR  - 2.	Morinville, V. D., Lowe, M. E., Ahuja, M., Barth, B., Bellin, M. D., Davis, H., et.al. Design and implementation of INSPPIRE. J Pediatr Gastroenterol Nutr. 2014;59(3):360-364. doi:10.1097/MPG.0000000000000417.
CR  - 3.	Morinville V.D, Husain S.Z, Bai H, Barth B, Alhosh R, Durie P.R, et al. Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr. 2012;55(3):261-265. doi:10.1097/MPG.0b013e31824f1516
CR  - Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-184. doi:10.1038/s41575-018-0087-5
CR  - Poddar U, Yachha SK, Borkar V, Srivastava A, Kumar S. A Report of 320 Cases of Childhood Pancreatitis. Pancreas. 2017;46(1):110-115. doi:10.1097/MPA.0000000000000733
CR  - Kandula L, Lowe ME. Etiology and Outcome of Acute Pancreatitis in Infants and Toddlers. J Pediatr. 2008;152(1):106-110.e1. doi:10.1016/J.JPEDS.2007.05
CR  - Pant C, Deshpande A, Olyaee M, Anderson M P, Bitar A, Steele M.I, et al. Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009. Rakonczay Z, ed. PLoS One. 2014;9(5):e95552. doi:10.1371/journal.pone.0095552
CR  - Ünlüsoy Aksu A, Sarı S, Eğritaş Gürkan Ö, Dalgıç B. Türk çocuklarda pankreatit: tek merkez deneyimi. Cukurova Med J. 2019;44(3):1-1. doi:10.17826/cumj.511605
CR  - Alabdulkareem A, Almahmoud T, Al-Tahan H, Javad S, Al Hatlani M. Etiology and clinical characteristics of pediatric acute pancreatitis in Saudi Arabia: a 20-year experience from a single tertiary center. Int J Pediatr Adolesc Med. 2018;5(1):13-17. doi:10.1016/j.ijpam.2018.01.001
CR  - Bai HX, Lowe ME, Husain SZ. What have we learned about acute pancreatitis in children? J Pediatr Gastroenterol Nutr. 2011;52(3):262-270. doi:10.1097/MPG.0b013e3182061d75
CR  - Taylor C.J, Chen K, Horvath K, Hughes D, Lowe M.E, Mehta D, et al. ESPGHAN and NASPGHAN Report on the Assessment of Exocrine Pancreatic Function and Pancreatitis in Children. 2015. doi:10.1097/MPG.000000000000083
CR  - .      Abu-El-Haija M, Kumar S, Quiros J.A, Balakrishnan K, Barth B, Bitton S, et al. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr. 2018; 66(1):159-176. doi:10.1097/MPG.0000000000001715
UR  - https://doi.org/10.12956/tchd.600267
L1  - https://dergipark.org.tr/tr/download/article-file/1019672
ER  -