TY  - JOUR
T1  - ANTIBACTERIAL CHARACTERISTICS OF NANOFIBER STRUCTURES OBTAINED BY BENZALKONIUM CHLORIDE ADDITIVE POLY (VINYL ALCOHOL)/GELATIN
TT  - Benzalkonyum Klorür Katkılı PVA/Gelatin Nanolif Yapılarının Antibakteriyel Özellikleri
AU  - Yüksek, Metin
AU  - Yolay, Onur
AU  - Tezcan, Erdem
AU  - İşgören, Erkan
AU  - Saltık, Derya
AU  - Çalışkan, Fatmagül
PY  - 2019
DA  - December
DO  - 10.7240/jeps.608954
JF  - International Journal of Advances in Engineering and Pure Sciences
JO  - JEPS
PB  - Marmara Üniversitesi
WT  - DergiPark
SN  - 2636-8277
SP  - 122
EP  - 127
VL  - 31
LA  - en
AB  - Polyvinylalcohol (PVA) is a hydrophilous and semi-crystallized. It has attracted muchrelevancy due to its pretty chemical endurance, fine thermal determination,decent physical specialities, wonderful bio-compatibility and cheapness.Gelatin (G) is a natural polymer and that are interesting materials forbiomedical applications. Electrospinning is a simple method that provides veryporous nanofiber production with high surface area. It is possible to producebiomedical, filtration, energy storage and protective materials by usingelectrospinning method. Benzalkonium chloride (BAC) is a kind of anti-microbialcationic surface-active agent, which has been pretty used in merchant wounddressings and has a powerful status toward Gr+ bacteria. In this study, nanofibers wereproduced from electrospinning of BAC, PVA and G containing solutions at variousconcentrations. The fibers of obtained nanofiber structure were uniform,continuous and intensive. The optimum parameters in terms of good mechanicaland antibacterial properties were determined. S2 sample, electrospun from 11.63% PVA + 1.0% G +1.0% BACcontaining solution, had the best morphological and mechanical properties dueto having the thinnest fiber diameter (51±13nm) and the highest verticalstrength (4.299MPa) and horizontal strength (4.058MPa). It also had antibacterialactivity against all the bacteria tested (E.coli,P.aeruginosa, B.subtilis and S.aureus). Due to owninggood mechanical and antibacterial properties, S2 sample can have many uses inmedical sector.
KW  - Electrospinning
KW  - poly(vinyl alcohol)
KW  - gelatin
KW  - benzalkonium chloride
KW  - antibacterial
KW  - nanofiber
N2  - Poli (vinil alkol) (PVA), iyi kimyasal dayanımı, iyi termal kararlılığı, iyi fiziksel özellikleri, mükemmel biyouyumluluğu ve ucuzluğu nedeniyle çok dikkat çeken hidrofilik, yarı kristalli bir polimerdir.Jelatin (G)biyomedikal uygulamalar için ilginç vedoğal bir polimerdir.Elektroeğirme, yüksek yüzey alanına sahip çok gözenekli nano elyaf üretimi sağlayan basit bir yöntemdir.Elektrospinning yöntemi kullanılarak biyomedikal, filtrasyon, enerji depolama ve koruyucu malzemeler üretmek mümkündür.Benzalkonyum klorür (BAC), ticari yara sargısında yaygın olarak kullanılan ve Gram-pozitif bakterilere karşı güçlü bir role sahip olan bir tür antimikrobiyal katyonik yüzey aktif malzemedir.Bu çalışmada, çeşitli konsantrasyonlarda BAC, PVA ve G içeren çözeltilerin nano lifler üretilmiştir.Elde edilen nano lif yapısının lifleri homojen, sürekli ve yoğundur. İyi mekanik ve antibakteriyel özellikler açısından optimum parametreler belirlenmiştir.11.63% PVA + 1.0% G +1.0% BAC içeren S2 örneği en iyi morfolojik ve mekanik özellikler göstermesinin yanındaen ince elyaf çapına (51 ± 13nm) ve en yüksek dikey dayanıma (4.299MPa) ve yatay dayanıma (4.058MPa) sahiptir. Ayrıca test edilen tüm bakterilere(E. coli, P. aeruginosa, B. subtilis ve S. aureus)karşı antibakteriyel aktiviteye sahiptir.İyi mekanik ve antibakteriyel özelliklere sahip olması nedeniyle, S2 örneğinin tıbbi sektörde birçok kullanımı olabileceği sonucuna ulaşılmıştır.
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UR  - https://doi.org/10.7240/jeps.608954
L1  - https://dergipark.org.tr/tr/download/article-file/875694
ER  -