@article{article_615454, title={An Analysis of Plasma Thiol/Disulphide Homeostasis in Patients with Stable Angina}, journal={Online Turkish Journal of Health Sciences}, volume={5}, pages={318–323}, year={2020}, DOI={10.26453/otjhs.615454}, author={Yazar, Hayrullah and Yıldız, Esra and İnci, Mustafa Baran and Çakar, Mehmet Akif and Özbek, Betül and Bal, Ceylan and Erel, Özcan}, keywords={Serbest tiyol,total tiyol,tiyol/disülfid,disülfid,stabil angina}, abstract={<div style="text-align:justify;"> <span style="font-size:14px;">Objective: To investigate thiol/disulfide homeostasis in patients with stable angina pectoris. </span> </div> <div style="text-align:justify;"> <span style="font-size:14px;">Materials and Methods: The study population consisted of 85 stable angina pectoris patients and 31 healthy volunteers. To compare the thiol/disulfide values of the patients and controls, the newly developed analysis method was used by Erel and Neselioglu. Disulfide/total thiol, free thiol/total thiol and disulfide/free thiol values were calculated for both groups. </span> </div> <div style="text-align:justify;"> <span style="font-size:14px;">Results: Disulfide, free thiol and total thiol values obtained in the study were; 18.00 µmol/L, 365.08 µmol/L, 401.10 µmol/L for the patient group and 9.67 µmol/L for the control group, 372.51 µmol/L, 391.85 µmol/L for the control group. It is the first time thiol/disulphide homeostasis in plasma was examined by new developed method in stable angina pectoris patients with this study. Disulfide, disulfide/free thiol and disulfide/total thiol values were significantly higher in the patient group compared to the control group. free thiol/total thiol levels were significantly lower in patients (p<0.001). </span> </div> <div style="text-align:justify;"> <span style="font-size:14px;">Conclusion: Thiol and disulfide values can be seen at high levels in patients with stable angina pectoris, so thiol/disulfide homeostasis may be an indicator for this disease. </span> </div>}, number={2}, publisher={Oğuz KARABAY}