TY - JOUR T1 - Obez Çocuk ve Adolesanlarda Hematolojik Parametreler ve Demir Düzeyinin Değerlendirilmesi TT - Evaluation of Hematological Parameters and Iron Level in Obese Children and Adolescents AU - Çağlar Şimşek, Cemile Ece AU - Çelik, Nurullah AU - Aygüneş, Utku AU - Yavuz Dönmez, Amine AU - Avcı, Ezgi AU - Ekici, Mahmut PY - 2019 DA - September DO - 10.17098/amj.624400 JF - Ankara Medical Journal JO - Ankara Med J PB - Ankara Yıldırım Beyazıt Üniversitesi WT - DergiPark SN - 2148-4570 SP - 479 EP - 487 VL - 19 IS - 3 LA - tr AB - Amaç: Bu çalışmanın amacı farklı yaş gruplarındaki obez çocuk veadolesanlarda hematolojik parametreler ve demir düzeylerini araştırmaktır.Materyal ve Metot: Bu çalışmaya Cumhuriyet Üniversitesi Tıp Fakültesi, ÇocukEndokrinoloji Polikliniğinde takip edilen, 3-18 yaş arası yüz ellidört çocuk veadolesan dahil edilmiştir. Kontrol grubu olarak ise, yaş ve cinsiyetleribenzer, sağlıklı 158 çocuk alınmıştır. Çocuklar yaş gruplarına göre, Grup 1(3-7 yaş), Grup 2 (7-12 yaş) ve Grup 3 (12-18 yaş) olmak üzere 3’e ayrıldı.Hematolojik parametreler, serum demir, demir bağlama kapasitesi(FeBK) veferritin düzeyleri karşılaştırıldı, Vücut Kitle İndeksi(VKI) ile olankorelasyonları araştırıldı.Bulgular: Kontrol(10,66±3,40; %55,8 kız) ve vaka (10± 4,16; %62 kız) gruplarında yaş ortalamalrıbenzerdi. Serum demir, FeBK, transferrin saturasyonu ve ferritin düzeylerikarşılaştırıldığında ise 12-18 yaş grubunda, obez çocuklarda, serum demiri vetransferrin saturasyonu daha düşükken, ferritin düzeyi ve FeBK daha yüksekti(p<0,001). 7-12 yaş grubunda ise obez çocuklarda ferritin düzeyi ve FeBKdaha yüksekken diğer parametreler benzerdi. Vücut kitle indeksi standart sapma(VKI-SDS) ile hematolojik parametrelerin korelasyonları karşılaştırıldığında,VKI-SDS Beyaz Küre Sayısı (r=0,46, p<0,001), Absolü Nötrofil Sayısı (r=0,40,p<0.001) ve Ferritin (r=0,36, p<0,001) ile pozitif korelasyongösterirken, Transferrin Saturasyon Yüzdesi ile negatif bir korelasyon (r=-0,22, p=0,02 ) gösteriyordu.Sonuç: Obezadolesanlar düşük saturasyon indeksi nedeni ile demir eksikliğine yatkındırlar.Obezlerde demir durumu araştırılırken ferritin düzeyi tek başına yanıltıcıolabilir. KW - Çocuklar KW - obezite KW - demir eksikliği KW - ferritin N2 - Objectives: The aim of thestudy was to investigate hematological parameters and iron level in obesechildren and adolescents in different age groups.Materials and Methods: The studypopulation consisted of hundred-fifty four obese children and adolescents agedbetween 3 and 18 years, who were being followed at the Cumhuriyet UniversityFaculty of Medicine Hospital, Pediatric Endocrinology Clinic. As the controlgroup, 158 healthy age and sex-matched children were also included. Thechildren were divided into three groups according to age: Group 1 (3-7 years),Group 2 (7-12 years), and Group 3 (12-18 years). Hematological parameters,serum iron, total iron-binding capacity, and ferritin levels were compared, andtheir correlations with body mass index(BMI) were investigated.Results: The mean ages of thecontrol (10,66±3,40; %55,80 girls) and case (10± 4,16; %62 girls) groups weresimilar. When compared serum iron, total iron-binding capacity, transferrinsaturation and ferritin levels, in obese children aged between 12-18 years,serum iron and transferrin saturation was lower whereas ferritin level andtotal iron-binding capacity were higher (p<0,001). On the other hand, theferritin level and total iron-binding capacity were higher in obese childrenaged between 7-12 years, while the other parameters were similar. When thecorrelations between BMI-SDS and hematological parameters were evaluated;positive correlations with white blood cell count (r = 0.46, p< 0.001),absolute neutrophil count (r = 0.40, p< 0.001) and ferritin levels (r =0.36, P <0.001), while a negative correlation with transferrin saturationpercentage (r = -0.22, p = 0.02) were found.Conclusion: Obese adolescents areprone to iron deficiency with low saturation index. Therefore ferritin levelmay be misled for investigating iron deficiency status in obese adolescents CR - 1. Finucane MM, Stevens GA, Cowan MJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 2011;377:557-67. CR - 2. Doak CM, Visscher TL, Renders CM, Seidell JC. The prevention of overweight and obesity in children and adolescents: a review of interventions and programmes. 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