TY - JOUR T1 - KARACİĞER BİYOPSİ İLE NONALKOLİK YAĞLI KARACİĞER HASTALIĞI TANISI ALAN 220 HASTANIN RETROSPEKTİF DEĞERLENDİRİLMESİ TT - RETROSPECTIVE EVALUATION OF 220 PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE DIAGNOSED BY LIVER BIOPSY AU - Oral, Alihan AU - Şahin, Tolga PY - 2020 DA - January JF - International Anatolia Academic Online Journal Health Sciences JO - IAAOJH PB - Abdülkadir IŞIK WT - DergiPark SN - 2148-3159 SP - 50 EP - 64 VL - 6 IS - 1 LA - tr AB - Non alkolik yağlı karaciğer hastalğı (NAYKH)alkol tüketimi olmadan karaciğer yağlanması olarak tanımlanır. NAYKH, dünyadaen sık görülen kronik karaciğer hastalığı olarak bilinir. NAYKH, siroz vehepatoselüler kanser gibi ciddi hastalıklara sebep olabilmektedir. Bu çalışmadakaraciğer biyopsisi ile NAYKH tanısı alan 220 hastayı retrospektifolarak değerlendirmeyi amaçladık. Araştırmaya 2010-2019 yılları arasındaDemiroğlu Bilim Üniversitesi Tıp Fakültesi gastroenteroloji polikliniğindetakip edilen karaciğer biyopsi ile NAYKH tanısı alan toplam 220 hasta alındı.Olguların demografik (yaş, cinsiyet, boy, kilo, beden kitle indeksi (BMI),laboratuvar (biyokimyasal parametreler) ve biyopsi sonuçları hastane bilgisisteminden ve dosyalarından retrospektif olarak toplandı. Hastaların yaş ortalaması 34.14 ± 6.72 ve % 60’ı erkek, % 40’ıkadındı. Erkek ve kadın hastalarda karaciğer yağlanma yüzdesi ortalamasıbenzerdi (p: 0.41). Hastaların BMI ortalaması: 27.32 ± 3.02, ortalama karaciğersteatoz yüzdesi % 12.1 ± 8.68 ve ortalama Homeostatic Model of Assessment-InsulinResistance (HOMA-IR) değeri 2.64 saptandı. Yağlanma derecesi ile BMI, aspartataminotransferaz, alanin aminotransferaz, alkalen fosfataz, gamaglutamiltransferaz, total kolesterol, trigliserit , kreatinin ve HOMA-IR arasındapozitif korelasyon saptanırken yaş, üre ve total biluribin ile herhangi birkorelasyon belirlenmedi. Çalışmamızdagenç ve orta yaş grubu ile obez olmayan kişilerde de NAYKH görülebileceği, BMIve insülin direncinin bu hasta grubunda da NAYKH ile ilişkili olabileceği gözlendi.Ayrıca, karaciğer enzimleri normal aralıkta olsa bile NAYKH ile ilişkiliolabilecekleri görülmüştür. Yeni ve daha geniş kapsamlı çalışmalarla, bu konudadaha güvenilir veriler elde edilebileceği düşünülmektedir. KW - Karaciğer yağlanması KW - NAFLD KW - hepatosteatoz N2 - Non-alcoholic fatty liver disease (NAFLD)defined as fatty accumulation in liver without alcohol consumption. NAFLD isknown as the most common chronic liver disease worldwide. NAFLD can cause serious diseases such ascirrhosis and hepatocellular cancer (HCC). We aimed to evaluate retrospectively220 liver biopsy proven patients with NAFLD in this study. A total of 220 patients diagnosed with NAFLDby liver biopsy followed in the gastroenterology outpatient clinic of DemiroğluBilim University Faculty of Medicine between 2010-2019 were included in thestudy. Demographic data (age, gender, height, weight and body mass index),biochemical laboratory parameters and biopsy results were scanned and recordedretrospectively from hospital information system and files of patients. The mean age of the patients was 34.14 ± 6.72and 60% of the patients were male and 40% were female. Mean liver steatosispercentage was similar in male and female patients (p: 0.41). The mean BMI ofthe patients was 27.32 ± 3.02, the mean liver steatosis percentage was 12.1 ±8.68% and the mean Homeostatic Model of Assessment-Insulin Resistance (HOMA-IR)value was 2.64. 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The Association Between Non-Alcholic Fatty Liver Disease with Carotid Intima Media Thickness. J. Kartal. TR 2015;26,:13–8. UR - https://dergipark.org.tr/tr/pub/iaaojh/issue//627034 L1 - https://dergipark.org.tr/tr/download/article-file/875172 ER -