@article{article_634978, title={The Application of Lipoic Acid in Experimentally Induced Tympanosclerosis in Rats}, journal={Journal of Contemporary Medicine}, volume={10}, pages={70–74}, year={2020}, DOI={10.16899/jcm.634978}, author={Turan, Fatih and Sayar, İlyas and Salcan, İsmail}, keywords={Alfa-Lipoik asit,inflamasyon,fibroz}, abstract={<p>Abstract </p> <p> <span style="font-weight:700;color:rgb(51,51,51);font-size:12.6px;text-align:justify;"> <span lang="en-us" xml:lang="en-us" style="font-size:12pt;line-height:32px;font-family:’Times New Roman’, serif;">Background/Aims: </span> </span> <span style="font-family:’Times New Roman’, serif;font-size:12pt;text-align:justify;">Tympanosclerosis
is an abnormal tissue reaction resulting in sclerotic and hyalinization changes
in the tympanic membrane and middle ear. </span> <span style="font-family:’Times New Roman’, serif;font-size:12pt;text-align:justify;">  </span> <span style="font-family:’Times New Roman’, serif;font-size:12pt;text-align:justify;">We hypothesized that alpha lipoic acid, an antioxidant, may represent a
simple and effective form of treatment in </span> <a style="font-family:’Times New Roman’, serif;font-size:12pt;text-align:justify;background-color:rgb(255,255,255);">inflammattion-related </a> <span style="font-family:’Times New Roman’, serif;font-size:12pt;text-align:justify;">tympanosclerosis. The purpose of the study was to investigate the effects
of alpha lipoic acid on experimentally induced inflammattion-related tympanosclerosis
in rats. </span> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> </p> <p> </p> <p> <span style="font-weight:700;color:rgb(51,51,51);font-size:12.6px;text-align:justify;"> <span lang="en-us" xml:lang="en-us" style="font-size:12pt;line-height:32px;font-family:’Times New Roman’, serif;">Methods: </span> </span> <span style="font-family:’Times New Roman’, serif;font-size:12pt;text-align:justify;">Twenty
albino Wistar rats were randomly divided into two equal groups. The first
(study) group was administered 50 mg/kg alpha lipoic acid by the intraperitoneal
route once daily for 7 days. The second group was administered the same saline
solution intraperitoneally once daily for 7 days. Inflammation, fibrosis and
lamina propria thickness were assessed at the subsequent histopathological
examination. </span> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> </p> <p> </p> <p> <span style="font-weight:700;color:rgb(51,51,51);font-size:12.6px;text-align:justify;"> <span lang="en-us" xml:lang="en-us" style="font-size:12pt;line-height:32px;font-family:’Times New Roman’, serif;">Results: </span> </span> <span style="font-family:’Times New Roman’, serif;font-size:12pt;text-align:justify;">In
the study group, significantly less middle ear inflammation and fibrosis
developed and the tympanic membrane lamina propria was thinner compared to the control
group.  </span> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> </p> <p> </p> <p> <span style="font-weight:700;color:rgb(51,51,51);font-size:12.6px;text-align:justify;"> <span lang="en-us" xml:lang="en-us" style="font-size:12pt;line-height:32px;font-family:’Times New Roman’, serif;">Conclusions:  </span> </span> <span style="font-family:’Times New Roman’, serif;font-size:12pt;text-align:justify;">Alpha
lipoic acid was found capable of preventing experimentally induced inflammattion-related
tympanosclerosis with its antioxidant characteristics. </span> </p> <p class="MsoNormal" style="text-align:justify;line-height:200%;"> <span lang="en-us" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> <b> </b> </span> </p> <p> <b> </b> </p> <b> </b> <p> <span style="font-weight:700;color:rgb(51,51,51);font-size:12.6px;text-align:justify;"> <span lang="en-us" xml:lang="en-us" style="font-size:12pt;line-height:32px;font-family:’Times New Roman’, serif;"> <br /> </span> </span> <span style="font-weight:700;color:rgb(51,51,51);font-size:12.6px;text-align:justify;"> <span lang="en-us" xml:lang="en-us" style="font-size:12pt;line-height:32px;font-family:’Times New Roman’, serif;"> <br /> </span> </span> </p> <p> <span style="font-weight:700;color:rgb(51,51,51);font-size:12.6px;text-align:justify;"> <span lang="en-us" xml:lang="en-us" style="font-size:12pt;line-height:32px;font-family:’Times New Roman’, serif;"> <br /> </span> </span> <br /> </p>}, number={1}, publisher={Rabia YILMAZ}, organization={Erzincan University Committee for Scientific Research Projects.}