TY  - JOUR
T1  - Metastatik Meme Kanserli Hastaların Klinik Özellikleri ve Tedavi Sonuçları: Tek Merkez Deneyimi
TT  - Clinical Features and Treatment Results of Metastatic Breast Cancer Patients: A Single Center Experience
AU  - Büyükşimşek, Mahmut
AU  - Paydaş, Semra
AU  - Başdoğan, Servet
AU  - Toğun, Mustafa
AU  - Yetişir, Abdullah Evren
AU  - Mirili, Cem
AU  - Oğul, Ali
AU  - Tohumcuoğlu, Mert
PY  - 2020
DA  - June
Y2  - 2020
DO  - 10.21673/anadoluklin.641856
JF  - Anatolian Clinic the Journal of Medical Sciences
JO  - Anadolu Klin
PB  - Hayat Sağlık ve Sosyal Hizmetler Vakfı
WT  - DergiPark
SN  - 2149-5254
SP  - 75
EP  - 80
VL  - 25
IS  - 2
LA  - tr
AB  - Amaç:Meme kanserikadınlarda en sık görülen ve en sık ölüme neden olan kanserdir. Bizde merkezimizde takip ettiğimiz metastatik meme kanseri (MMK) olan hastaların kliniközelliklerini ve tedavi sonuçlarını araştırmak istedik.Gereçve Yöntemler: ÇukurovaÜniversitesi Onkoloji bilim dalında 2011-2017 yılları arasında takip edilen 65 MMKolan hasta çalışmaya dahil edildi. Hastaların klinik özellikleri ve aldıklarıtedaviler retrospektif olarak araştırıldı.Bulgular:Hastaların büyükçoğunluğunda sadece kemik metastazı vardı. Sonradan metastatik evreye geçen 45hastanın %66,6’ sına yeniden biyopsi yapıldı; bu hastaların %20’ sinde tümörbiyolojisi değişmişti. Metastatik evrede progresyonsuz sağkalım 10 ay, ortalamasağkalım 34 ay olarak hesaplandı.Tartışma ve Sonuç: MMKolan hastalarda literatürle uyumlu sağkalımlar elde edilmiştir. Yeni kullanımagiren ajanlar ve hedefleyici tedavilerdeki gelişmeler de göz önüne alındığındahastalık biyolojisindeki değişme ihtimali göz önünde bulundurularak relapslardayeniden biyopsi yapılması kritik önemdedir.
KW  - metastatik meme kanseri
KW  - sağkalım sonuçları
KW  - kemoterapi
KW  - hedefleyici tedaviler
N2  - Aim: Breastcancer is the most common cancer that causes death in women. We wanted to investigatethe clinical features and treatment results of patients with metastatic breastcancer. Materials and Methods:Sixty-five patients with metastatic breast cancer followed in the OncologyDepartment of Cukurova University between 2011 and 2017 were included in thestudy. The clinical features and treatments of the patients were investigatedretrospectively.Results: Themajority of patients had only bone metastases. Re-biopsy was performed in 66,6%of 45 patients who subsequently underwent metastatic stage; and tumor biologyhad changed in 20% of these patients. The progression-freesurvival in the metastatic stage was 10 months and the overall survival was 34months.Discussion and Conclusion:Survivalof patients with metastatic breast cancer is consistent with the literature.When new agents and new therapies are also taken into consideration, re-biopsyat relapses is critical in considering the possibility of changes in diseasebiology.
CR  - Referans1 Winters S, Martin C, Murphy D, Shokar NK. Breast Cancer Epidemiology, Prevention, and Screening. Prog Mol Biol Transl Sci. 2017;151:1-32. doi: 10.1016/bs.pmbts.2017.07.002.
CR  - Referans2 Güth U, Elfgen C, Montagna G, Schmid SM. Long-Term Survival and Cure in Distant Metastatic Breast Cancer. Oncology. 2019;97(2):82-93. doi: 10.1159/000500298. Epub 2019 May 3.
CR  - Referans3 Hammond ME, Hayes DF, Dowsett M, Allred DC, Hagerty KL, Badve S, ve ark. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version). Arch Pathol Lab Med. 2010 Jul;134(7):e48-72.  Referans4 Bansal C, Singh US, Misra S, Sharma KL, Tiwari V, Srivastava AN. Comparative  evaluation of the modified Scarff-Bloom-Richardson grading system on breast carcinoma aspirates and histopathology. Cytojournal. 2012;9:4.
CR  - Referans5 Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B,  Senn HJ. Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011 Aug;22(8):1736-47.
CR  - Referans6 Ogiya R, Sagara Y, Niikura N, Freedman RA. Impact of Subtype on Survival of Young Patients With Stage IV Breast Cancer. Clin Breast Cancer. 2019 Jun;19(3):200-207.e1. doi: 10.1016/j.clbc.2019.01.005.
CR  - Referans7 Leone BA, Vallejo CT, Romero AO, Machiavelli MR, Pérez JE, Leone J, ve ark. Prognostic impact of metastatic pattern in stage IV breast cancer at initial diagnosis. Breast Cancer Res Treat. 2017 Feb;161(3):537-548. doi: 10.1007/s10549-016-4066-7.
CR  - Referans8 Andre F, Slimane K, Bachelot T, Dunant A, Namer M, Barrelier A, ve ark. Breast cancer with synchronous metastases: trends in survival during a 14-year period. J Clin Oncol. 2004 Aug 15;22(16):3302-8.
CR  - Referans9 Dawood S, Broglio K, Ensor J, Hortobagyi GN, Giordano SH. Survival differences among women with de novo stage IV and relapsed breast cancer. Ann Oncol. 2010 Nov;21(11):2169-74. doi: 10.1093/annonc/mdq220.
CR  - Referans10 Pal SK, Dehaven M, Nelson RA, Onami S, Hsu J, Waliany S, ve ark. Impact of modern chemotherapy on the survival women presenting with de no metastatic breast cancer. BMC Cancer. 2012 Sep 28;12:435. doi: 10.1186/1471-2407-12-435. Referans11 Lobbezoo DJ, van Kampen RJ, Voogd AC, Dercksen MW, van den Berkmortel F, Smilde TJ, ve ark. In real life, one-quarter of patients with hormone receptor-positive metastatic breast cancerreceive chemotherapy as initial palliative therapy: a study of the Southeast Netherlands Breast Cancer Consortium. Ann Oncol. 2016 Feb;27(2):256-62. doi: 10.1093/annonc/mdv544. Referans12 Amir E, Clemons M, Purdie CA, Miller N, Quinlan P, Geddie W, ve ark. Tissue confirmation of disease recurrence in breast cancer patients: pooled analysis of multi-centre, multi-disciplinary prospective studies. Cancer Treat Rev. 2012 Oct;38(6):708-14. doi: 10.1016/j.ctrv.2011.11.006.
CR  - Referans13 de Dueñas EM, Hernández AL, Zotano AG,  Carrión RM, López-Muñiz JI, Novoa SA, ve ark. Prospective evaluation of the conversion rate in the receptor status between primary breastcancer and metastasis: results from the GEICAM 2009-03 ConvertHER study. Breast Cancer Res Treat. 2014 Feb;143(3):507-15. doi: 10.1007/s10549-013-2825-2.
UR  - https://doi.org/10.21673/anadoluklin.641856
L1  - http://dergipark.org.tr/tr/download/article-file/1150089
ER  -