@article{article_64250, title={Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease}, journal={Dicle Medical Journal}, volume={39}, pages={325–330}, year={2012}, DOI={10.5798/diclemedj.0921.2012.03.0152}, author={Kutlucan, Ali and Tunc, Sevket Ercan and Baltacı, Davut and Sahin, Mehmet and Ozsahin, Mustafa and Sütcü, Recep and Ermis, Fatih and Süslü, Harun}, keywords={Behçet hastalığı, osteoprotegerin, TNF-α, osteokalsin}, abstract={Objectives: Osteoporosis is commonly developed due to <br />natural course of Behçet’s disease (BD) and therapeutic <br />agents. It was aimed to investigate levels of osteoprotegerin <br />and TNF-α (tumor necrosis factor), and bone mineral density <br />(BMD) and correlation between them in BD. <br />Materials and methods: The study included two groups <br />as the study and the control group. Serum levels of TNF-α, <br />osteoprotegerin, osteocalcine, erythrocyte sedimentation rate <br />(ESR), C-reactive protein (CRP), and urinary creatinine and <br />deoxypyridinoline along with BMD level were evaluated and <br />compared. Correlation between TNF-α and osteoprotegerin <br />level was investigated. <br />Results: The study enrolled 41 BD patients and 36 agedmatched control subjects. Mean age was 42.26±11.64 and <br />41.66±70.99, in the study and control groups, respectively. <br />There was no significant difference in body mass index <br />(BMI) of subjects between groups (p>0.05). Level of TNF-α <br />(p<0.001), deoxypyridinoline (p<0.001) and osteocalcine <br />(p=0.041) was significantly higher in the study group compared to the control group. Osteoprotegerin was lower in <br />BD patients, but the difference was not significant (p>0.05). <br />Urinary deoxypyridinoline/ urinary creatinine ratio in patients <br />with BD was significantly higher than those in control group <br />(p=0.030). Patients had significantly lower BMD comparfed <br />to the control group, except L2-L4 vertebral area (p<0.001, <br />p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 and <br />p=0.111, respectively). No correlation was found between <br />TNF-α and osteoprotegerin. <br />Conclusions: The present study indicated that TNF-α and <br />BMD was negatively correlated with each other and TNF-α <br />had an effect on osteoporotic process in patients with BD. <br />Osteoprotegerin level was not decreased, and not correlated <br />with TNF-α.}, number={3}, publisher={Dicle Üniversitesi}