TY  - JOUR
T1  - Ülseratif kolit hastalarında nötrofil lenfosit oranı ve platelet lenfosit oranı, klinik ve endoskopik aktivite indeksleri ile ilişkili mi?
TT  - Do neutrophil-lymphocyte ratio and platelet-lymphocyte ratio correlate with clinical and endoscopic activity indices in ulcerative colitis patients?
AU  - Yalaki, Serkan
AU  - Yalçın, Mehmet Suat
AU  - Pulat, Hüseyin
AU  - İlhan, Aysu
PY  - 2020
DA  - April
DO  - 10.17940/endoskopi.646673
JF  - Endoskopi Gastrointestinal
PB  - Türk Gastroenteroloji Vakfı
WT  - DergiPark
SN  - 1302-5422
SP  - 5
EP  - 11
VL  - 28
IS  - 1
LA  - tr
AB  - Amaç:Ülseratifkolitin (ÜK) hastalık aktivitesine ve ciddiyetine göre sınıflandırılması klinikuygulamada önemlidir, çünkü hastanın yönetimini belirler. Bu çalışmada,nötrofil lenfosit oranları (NLR) ve platelet lenfosit oranlarının (PLR), ÜKhastalarında klinik aktivite indeksinin (KAİ) yanı sıra mukozal hastalığa görehastalık şiddetini belirleyen endoskopik aktivite indeksleri (EAİ) ile olanilişkilerinin ortaya konulması amaçlanmıştır.Materyalve Metot: Çalışma retrospektif tek merkezli çalışma olarakplanlandı. Yeni tanı almış 99 ÜK’li hastadan KAİ’lerine ve EAİ’lerine göreaktif hastalık ve remisyon grupları oluşturuldu. Kontrol grubu 56 sağlıklıbireyden oluşturuldu.Bulgular:Klinikaktifhastaların serum NLR’ı ve PLR’ı, inaktif ÜK ve kontrol grubuna göre anlamlıderecede yüksekti (p<0,01). NLR ve PLR için kesme değerleri sırasıyla 2,10(%90 sensitivite, %45 spesifite) ve 152,13 (%70 sensitivite, %33 spesifite)olarak saptandı. Endoskopik aktif hastaların serum NLR’ı ve PLR’ı, inaktif ÜKve kontrol grubuna göre anlamlı derecede yüksekti (p<0,01). NLR ve PLR içinkesme değerleri sırasıyla 2,09 (%97 sensitivite, %39 spesifite) ve 151,72 (%73sensitivite, %31 spesifite) olarak saptandı.Sonuç: Çalışmamızaktif ÜK hastalarında NLR ve PLR seviyelerinin anlamlı şekilde arttığını vebunun klinik, endoskopik ve laboratuvar endeksleri ile korele olduğunugöstermiştir. Bu inflamatuar belirteçler tek başına ya da birlikte hastalıkaktivitesini tahmin edebilir.
KW  - Ülseratif kolit
KW  - Nötrofil lenfosit oranı
KW  - Platelet lenfosit oranı
KW  - Endoskopik aktivite indeksi
KW  - Klinik aktivite indeksi
N2  - Objective:Classificationof ulcerative colitis (UC) according to disease activity and severity isimportant in clinical practice because it determines the management of thepatient. In this study, we aimed to investigate the relationship betweenneutrophil lymphocyte ratios (NLR) and platelet lymphocyte ratios (PLR) withclinical activity index (CAI) in UC patients as well as endoscopic activityindexes (EIA) that determine disease severity relative to mucosal disease.Materialsand Methods: The study was planned as a retrospectivesingle-center study. Active disease and remission groups were formed from 99newly diagnosed UC patients according to their CAIs and EAIs. The control groupconsisted of 56 healthy subjects.Results:SerumNLR and PLR levels of clinically active patients were significantly higher thaninactive UC and control groups (p <0.01). The cut-off values for NLR and PLRwere 2.10 (90% sensitivity, 45% specificity) and 152.13 (70% sensitivity, 33%specificity), respectively. Serum NLR and PLR of endoscopically active patientswere significantly higher than inactive UC and control group (p <0.01). Thecut-off values for NLR and PLR were 2.09 (97% sensitivity, 39% specificity) and151.72 (73% sensitivity, 31% specificity), respectively.Conclusion:Ourstudy showed that NLR and PLR levels were significantly increased in active UCpatients and correlated with clinical, endoscopic and laboratory indices. Theseinflammatory markers can predict disease activity alone or in combination.
CR  - 1-	Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut, gutjnl–2019–318484.2-	Caprilli R, Viscido A, Latella G. Current management of severe ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol. 2007;4(2):92–101.3-	Lok KH, Ng CH, Hung HG, Li KF, Li KK, Szeto ML. (2008). Correlation of serum biomarkers with clinical severity and mucosal inflammation in Chinese ulcerative colitis patients. Journal of Digestive Diseases, 9(4), 219–224.4-	Hassan EA, Ramadan HK, Ismael AA, Mohamed KF, El-Attar MM, Alhelali I. Noninvasive biomarkers as surrogate predictors of clinical and endoscopic remission after infliximab induction in patients with refractory ulcerative colitis. Saudi J Gastroenterol. 2017 Jul-Aug; 23(4):238-245.5-	Vermeire S, Van Assche G, Rutgeerts P. Laboratory Markers in IBD: Useful, magic, or unnecessary toys? Gut 2006; 55: 426-431.6-	 Zahorec R. Ratio of neutrophil to lymphocyte counts — rapid and simple parameter of systemic inflammation and stress incritically ill. Bratisl Lek Listy 2001; 102:5—14.7-	Yodying H, Matsuda A, Miyashita M, Matsumoto S, Sakurazawa N, Yamada M, et al. Prognostic Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Oncologic Outcomes of Esophageal Cancer: A Systematic Review and Meta-analysis. Ann Surg Oncol. 2016 Feb;23(2):646-54.8-	Akpinar MY, OzinYO, Kaplan M, Ates I, Kalkan İH, Kilic ZMY et al.  Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio Predict Mucosal Disease Severity in Ulcerative Colitis . J Med Biochem. 2018 Apr; 37(2): 155–162.9-	Demir AK, Demirtas A, Kaya SU, Tastan I, Butun I, Sagcan M, Et al. The relationship between the neutrophilelymphocyte ratio and disease activity in patients with ulcerative colitis. Kaohsiung Journal of Medical Sciences (2015) 31, 585e590.10-	Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006; 55: 749-753.11-	Feagan BG, Greenberg GR, Wild G, Fedorak RN, Pare P, McDonald JW, et al. Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. New England Journal of Medicine 2005;352(24):2499‐507.12-	 Lee JS,  Kim ES,Won, Moon W Chronological Review of Endoscopic Indices in Inflammatory Bowel Disease. Clin Endosc. 2019 Mar; 52(2): 129–136.13-	 Rosenberg L, Lawlor GO, Zenlea T, Goldsmith JD, Gifford A, Falchuk KR, et al. Predictors of endoscopic onflammation in patients with ulcerative colitis in clinical remission. Inflamm Bowel Dis 2013; 19(4): 779–84.14-	 D’Haens, Sandborn WJ, Feagan BG, Geboes K, Hanauer SB, Irvine EJ, et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 2007; 132: 763–86.15-	Osada T, Ohkusa T, Okayasu I, Yoshida T, Hirai S, Beppu K, et al. Correlations among total colonoscopic findings, clinical symptoms, and laboratory markers in ulcerative colitis. J Gastroenterol Hepatol 2008; 23: S262e7.16-	Yoon JY, Park SJ, Hong SP, Kim TI, Kim WH, Cheon JH. Correlations of C-reactive protein levels and erythrocyte sedimentation rates with endoscopic activity indices in patients with ulcerative colitis. Dig Dis Sci 2014; 59: 829e37.17-	Karoui S, Laz S, Serghini M, Bibani N, Boubaker J, Filali A. Correlation of C-reactive protein with clinical and endoscopic activity in patients with ulcerative colitis. Dig Dis Sci 2011; 56: 1801—5.18-	C¸elikbilek M, Dogan S, Ozbakir O, Zararsiz G, Kucuk H, Gursoy S, et al. Neutrophil-lymphocyte ratio as a predictor of disease severity in ulcerative colitis. J Clin Lab Anal 2013; 27:72e6. 19-	Gewirtz AT, Liu Y, Sitaraman SV,Madara JL. Intestinal epithelial pathobiology: Past, present and future. Best Pract Res Clin Gastroenterol. 2002;16(6):851–867.20-	Posul E, Yilmaz B, Aktas G, Kurt M. Does neutrophil-tolymphocyte ratio predict active ulcerative colitis? Wiev Klin Wochenschr 2015; 127: 262–5.21-	Voudoukis E, Karmiris K, Koutroubakis IE. Multipotent role of platelets in inflammatory bowel diseases: a clinical approach. World J Gastroenterol. 2014;20(12):3180–3190.
UR  - https://doi.org/10.17940/endoskopi.646673
L1  - https://dergipark.org.tr/tr/download/article-file/1099567
ER  -