@article{article_647570, title={Relationship between fibromyalgia clinical and laboratory parameters with obesity}, journal={Pamukkale Medical Journal}, volume={13}, pages={207–214}, year={2020}, DOI={10.31362/patd.647570}, author={Deveci, Hülya}, keywords={Vitamin B12,Fibromyalji,Obezite,Kısa Form 36,Beck Depresyon Ölçeği,Vitamin B12}, abstract={ Purpose: Fibromyalgia syndrome (FMS) is a common disease characterized by diffuse pain. Obesity is also a common disease characterized by excessive fat accumulation in adipose tissue. Obese individuals are known to have more musculoskeletal pain than normal people. In this study, we aimed to evaluate the relationship between obesity and fibromyalgia clinical and laboratory parameters. Materials and Methods: The study included 50 FMS patients and 35 healthy control groups. FMS patients were divided into two subgroups according to their BMI: obese (BMI≥30) and non-obese (BMI<30). Clinical comparisons were made with Visual Analogue Scale (VAS), Fibromyalgia Impact Questionnaire (FEA), Short Form-36 (SF-36), and Beck Depression Inventory (BDI). In addition, serum CRP, vitamin B12, folate, TSH levels were compared. Results: BDI, SF-36 physical function score was significantly higher in the obese group compared to the non-obese and healthy control group ( p <0.001). Paresthesia and restless sleep symptoms were also significantly higher in the obese group than the non-obese group ( p <0.05). Serum vitamin B12 levels were significantly lower and serum CRP values were significantly higher in the obese FMS group than the non-obese FMS group ( p <0.001 and p <0.05, respectively). There was no statistically significant difference between groups in terms of VAS, FIQ score, pain duration, tender point count, serum TSH and folate levels. Conclusion: Obesity is thought to have an impact on the pathogenesis and prognosis of the disease in patients with FMS. The findings of our study support the FMS-obesity relationship in the literature. To clarify this relationship, prospective studies involving more patient groups and using better homogenized patients and control groups are needed. }, number={1}, publisher={Pamukkale Üniversitesi}