TY - JOUR T1 - Hemofagositik Lenfohistiyositozis AU - Bör, Özcan PY - 2004 DA - December JF - Güncel Pediatri PB - Galenos Yayınevi WT - DergiPark SN - 1304-9054 SP - 113 EP - 116 VL - 2 IS - 4 LA - tr AB - Hemofagositik lenfohistiyositozis HLH nadir görülen fatal seyirli bir fenomendir. Hemofagositozla karakterize malign olmayan immün regülasyon bozukluğudur. T lenfositler ve makrofajların kontrol edilemeyen aktivasyonu ve inflamatuar sitokinlerin İnterferon gama, interlökin-1, interlökin-6, tümör nekrozis faktör gibi aşırı üretimi vardır. CR - 1. Janka GE. Familial hemophagocytic lymphohistiocytosis. Eur J Pediatr, 1983; 140: 221-30. CR - 2. Henter JI, Elinder G, Öst A, and the FHL Study Group of the Histiocyte Society. Diagnostic guidelines for hemophagocytic lymphohistiocyto￾sis. Semin Oncol 1991;18: 29-33. CR - 3. Arico M, Janka G, Fischer A, et al. Hemophagocytic Lymphohistiocyto￾sis: Diagnosis, treatment and prognostic factors. 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