@article{article_677869, title={The Risk Factors for Autoimmune Thyroid Disorder in Children with Chronic Spontaneous Urticaria}, journal={Osmangazi Tıp Dergisi}, volume={43}, pages={1–6}, year={2021}, DOI={10.20515/otd.677869}, author={Eser Şimşek, Işıl and Abalı, Saygın and Çöğürlü, Müjde Tuba and Aydoğan, Metin}, keywords={kronik ürtiker, anti tiroid peroksidaz antikoru, tiroid otoimmünitesi, sistemik lupus eritematozus, vitiligo}, abstract={<p> </p> <div style="text-align:justify;"> <span style="font-size:.9em;">Although the etiology of chronic spontaneous urticaria (CSU) in children is mostly idiopathic, there are studies </span> <span style="font-size:.9em;">supporting the autoimmune pathogenesis of disease in a subset of patients. CSU and autoimmune thyroid disease coexistence has </span> <span style="font-size:.9em;">been explored mostly in adults; however data in children is scarce. The aim of this study was to verify frequency of anti thyroid </span> <span style="font-size:.9em;">peroxidase (anti-TPO) antibody positivity and risk factors for autoimmune thyroid disorder in the children with CSU. In this </span> <span style="font-size:.9em;">retrospective descriptive study, a total of 126 children with CSU in two different centers were evaluated. The demographic and </span> <span style="font-size:.9em;">clinical features, coexisting connective tissue diseases, autoimmune and/or allergic diseases and complete blood count, total IgE,  </span> <span style="font-size:.9em;">antinuclear antibody (ANA), anti-TPO antibody, free thyroxine (fT4), thyroid-stimulating hormone (TSH), skin prick test and </span> <span style="font-size:.9em;">autologous serum skin test (ASST) results that routinely performed for CSU in both centers were collected from medical records. </span> <span style="font-size:.9em;">Thyroid ultrasonography findings were also recorded in the patients with positive anti-TPO. Anti-TPO was positivite in 5 (4.0%)  </span> <span style="font-size:.9em;">patients. Heterogenous paranchyme on thyroid US was detected in 3 of those. ANA was positive 10.1% of the patients. In anti-TPO </span> <span style="font-size:.9em;">positive patients, ANA positivity was significantly higher (60% vs 7.4%, respectively; p=0.003). Vitiligo was detected in 4 (3.2%) </span> <span style="font-size:.9em;">of patients and although it is not significant statistically, these patients had higher frequency of anti-TPO positivity compare to those </span> <span style="font-size:.9em;">without vitiligo (20% vs 2.5%, respectively; p=0.151). ANA positivity may be a risk factor for autoimmune thyroid disorder in </span> <span style="font-size:.9em;">patients with chronic spontaneous urticaria. Relationship between vitiligo and autoimmun thyroid disorder should also be </span> <span style="font-size:.9em;">investigated in patients with CSU in larger cohorts </span> </div>}, number={1}, publisher={Eskişehir Osmangazi Üniversitesi}