TY - JOUR T1 - Yeni Schiff Bazlı Bileşiklerin Sentezi, Biyolojik Aktivite ve Moleküler Docking Çalışmaları TT - Synthesis, Biological Activities and Molecular Docking Studies of New Schiff Bases Derivatives AU - Ünlüer, Dilek AU - Ünver, Yasemin AU - Bektaş, Ersan AU - Direkel, Şahin AU - Karaman, Muhammet AU - Karaman, Halide Sedef PY - 2020 DA - July Y2 - 2020 DO - 10.17714/gumusfenbil.679313 JF - Gümüşhane Üniversitesi Fen Bilimleri Dergisi PB - Gümüşhane Üniversitesi WT - DergiPark SN - 2146-538X SP - 681 EP - 694 VL - 10 IS - 3 LA - en AB - Bu çalışmada,morfolinli (1,2) yeni tiyofen Schiff bazları sentezlenmiştir. Bileşiklerinyapıları, 1H-NMR, 13C-NMR ve IR spektrometrisi ile doğrulanarak antioksidan,antibakteriyel, antileishmanial ve enzim aktiviteleri test edilmiştir. Bileşik1 ve 2'den gözlemlenen antioksidan aktiviteler dikkat çekici derecede yüksekolarak belirlenmiştir. Çalışmamızda elde edilen sonuçlara göre, bileşiklerantileishmanial aktivite göstermemiştir (MIC> 20000 µg / ml). Sentezlenenbileşiklerin dokuz farklı standart bakteri izolatına karşı farklıantibakteriyel aktivite oranlarına sahip olduğu belirlenmiştir. Bileşik 1 ve2'nin enzim inhibisyon etkisi önemsiz düzeyde olup ve bu bileşikler molekülerdocking çalışmalarında enzimlere karşı düşük bağlanma afinitesisergilemişlerdir. Bileşik 1ve 2, aktif bölge kalıntısı ile birçok 𝜋 etkileşimi oluşturmuştur., Ancak, bu enzimlerinönemli kalıntıları ile etkileşimegirmediği için enzimleri inhibe etmemişleridir. In siliko ve in vitro çalışmasonuçları birbiri ile uyumludur. Sonuç olarak bileşikler 1 ve 2, ilaç olarakaraştırılırsa, antioksidan ve antimikrobiyal ilaçlar olarak kullanılabilir. KW - Antibakteriyel KW - Antileishmanial KW - Antioksidan KW - Enzim Aktivitesi KW - Morfolin KW - Schiff Bazı N2 - In this study, new thiopheneSchiff bases with morpholine (1,2) were synthesized. The structures of thecompounds were confirmed by 1H-NMR, 13C-NMR and IRspectrometry and their antioxidant, antibacterial,antileishmanial and enzyme activities were tested. The antioxidant activities observed from compounds1 and 2 were remarkably high. According to the resultsobtained in our study, the compounds did not have antileishmanial activity (MIC>20000 µg/ml). It was determined that the synthesized compounds had differentrates of antibacterial activity against nine different standard bacterialisolates. Enzyme inhibition effect of the compounds 1 and 2 was unimportantlevel and the compound exhibited low binding affinity against the enzyme inmolecular docking studies. The compounds 1 and 2 formed many 𝜋 interactions with active siteresidue, however, they do not inhibit the enzyme due to did not interact withkey residues of the enzymes. Our in silico and in vitro studies results werecompatible with each other. 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