TY  - JOUR
T1  - Synthesis and Characterization of New Compounds Including Propargyl Side Chain as Potential MAO-B Inhibitor
TT  - Potansiyel MAO-B İnhibitörü Olarak Propargil Yan Zinciri İçeren Yeni Bileşiklerin Sentezi ve Karakterizasyonu
AU  - Osmaniye, Derya
AU  - Özkay, Yusuf
PY  - 2020
DA  - December
Y2  - 2020
DO  - 10.35193/bseufbd.681580
JF  - Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi
PB  - Bilecik Şeyh Edebali Üniversitesi
WT  - DergiPark
SN  - 2458-7575
SP  - 755
EP  - 763
VL  - 7
IS  - 2
LA  - en
AB  - In this study, some new propargyl derivatives were synthesized considering potential monoamine oxidase-B (MAO-B) inhibition potency of propargyl moiety. In synthesis studies, 2-chlorobenzimidazole was reacted with propargyl bromide in the presence of NaH and compound 1 was obtained. Compound 1 was treated with various benzylamine derivatives and final products (2a-2c) were gained. Structures of obtained compounds were established by spectroscopic methods. Effects of the synthesized compounds against MAO enzymes were observed by using in-vitro fluorimetric method. Activity studies revealed that synthesis compounds inhibited MAO enzymes to different extends. .
KW  - Propargyl
KW  - Benzimidazole
KW  - NMR
KW  - Monoamine Oxydase
KW  - Parkinson’s Disease
N2  - Bu çalışma kapsamında, propargil grubunun Monoaminoksidaz-B (MAO-B) enzimi üzerindeki potansiyel inhibitör etkinliği dikkate alınarak bazı yeni propargil grubu içeren bileşikler sentezlenmiştir. Sentez çalışmalarında, 2- klorobenzimidazol NaH varlığında propargil bromür ile reaksiyona sokulmuş bileşik 1 elde edilmiştir. Bileşik 1 çeşitli benzilamin türevleri ile potasyum karbonat katalizörlüğünde muamele edilerek sonuç ürünlerine (2a-2c) ulaşılmıştır. Elde edilen bileşiklerin yapıları 1HNMR ve 13C-NMR ve HRMS spektroskopik yöntemleri ile doğrulanmıştır. Sentezlenen bileşiklerin MAO enzimleri üzerindeki etkileri in-vitro şartlarda florimetrik yöntem kullanılarak araştırılmıştır. Yapılan aktivite çalışmaları sonucunda sentezlenen bileşiklerin MAO enzimlerini değişen düzeylerde inhibe ettiği tespit edilmiştir.
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UR  - https://doi.org/10.35193/bseufbd.681580
L1  - https://dergipark.org.tr/tr/download/article-file/948311
ER  -