@article{article_688764, title={Propylthiouracil induced p-ANCA+ pyoderma gangrenosum: Case report and review of literature}, journal={Maltepe Tıp Dergisi}, volume={12}, pages={59–62}, year={2020}, DOI={10.35514/mtd.2020.30}, author={Uslu, Sadettin and Köken Avşar, Aydan and Karakas, Ali}, keywords={ANCA, PTU, Pyoderma Gangrenosum}, abstract={<p>Propylthiouracil (PTU) is a medication commonly used in the treatment of hyperthyroidism and is associated with the development of antineutrophil cytoplasmic antibodies (ANCA) in 20% of patients treated for Graves’ disease [1], [2]. ANCA-positive PTU-induced pyoderma gangrenosum (PG) was first identified in 1999 by Darben et al. [1]. ANCAs are found in the blood of many patients with necrotizing systemic vasculitis and in some patients with neutrophilic dermatoses such as drug-induced vasculitis, Sweet’s syndrome, Behçet’s disease and PG. Some reports have described the ANCA phenomenon in patients with PG or in neutrophilic dermatosis with the characteristics of PG [3]. We aimed to present development of PG with p-ANCA positivity in a patient who had been using PTU for a long time and to discuss the current literature with this case-based review. <br /> </p>}, number={2}, publisher={Maltepe Üniversitesi}