TY  - JOUR
T1  - miRNA’LAR VE KORONER ARTER HASTALIKLARIYLA İLİŞKİLERİ
TT  - Relations of mirna's and Coronary Artery Diseases
AU  - Padak, Mahmut
AU  - Dikme, Reşat
AU  - Korkmaz Ersöz, Ezhar
AU  - Hacanlı, Yasemin
PY  - 2020
DA  - April
Y2  - 2020
DO  - 10.33715/inonusaglik.700995
JF  - İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi
JO  - JHVS
PB  - İnönü Üniversitesi
WT  - DergiPark
SN  - 2147-7892
SP  - 162
EP  - 174
VL  - 8
IS  - 1
LA  - tr
AB  - Son çalışmalar, miRNA'ların kalbin gelişimi ve düzgün çalışması için çok önemli olduğunu göstermiştir. Kalbin kardiyojenik transkripsiyon faktörleri nedeniyle ifade edilen birçok miRNA'sı vardır. Kardiyovasküler hastalıklar sırasında miRNA ekspresyonu önemli ölçüde değişir ve farklı miRNA ekspresyon seviyeleri spesifik kardiyovasküler bozukluklarla korelasyon gösterir. Bu derleme makalesi miRNA'lar hakkında ayrıntılı bilgi vererek hem klinik hem de subklinik koroner arter hastalığı ile korelasyonu hakkındaki mevcut kanıtları özetlemekte, ayrıca miRNA'ların koroner arter hastalığında potansiyel bir tanı ve prognostik biyobelirteç olarak araştırmanın gerekliliğini vurgulamaktadır.
KW  - mikroRNA
KW  - miRNA
KW  - Koroner arter hastalığı
N2  - Recent studies have established that miRNAs are crucial for the development and proper functioning of the heart. The heart has many miRNAs expressed due to cardiogenic transcription factors. During cardiovascular diseases, miRNA expression varies significantly and different miRNA expression levels are correlated with specific cardiovascular disorders. This review article provides detailed information about miRNAs, summarizes the available evidence on the correlation of micro-RNAs with both the clinical and subclinical coronary artery disease and highlights the necessity for exploring miRNAs as a potential diagnostic and prognostic biomarker of early CAD.
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UR  - https://doi.org/10.33715/inonusaglik.700995
L1  - https://dergipark.org.tr/tr/download/article-file/1053417
ER  -