@article{article_72492, title={Evaluation of antimalarial potential of aqueous stem bark extract of Bombax buonopozense P. Beauv. (Bombacaceae)}, journal={EASTERN JOURNAL OF MEDICINE}, volume={17}, pages={72–77}, year={2013}, author={Iwuanyanwu, Tom Chinyere and Akuodor, Godwin Christian and Essien, Augustine Dick and Nwinyi, Florence Chidume and Akpan, Joseph Linus and Okorafor, Dorcas Okayo and Osunkwo, Uche Alex}, keywords={Antimalaria, bombax buonopozense, medicinal plant, mice, plasmodium berghei}, abstract={<div class="Section1"> <p class="Trkezet">Abstract. The treatment of malaria in Africa is becoming increasingly difficult due to rising prevalence of <em>plasmodium falciparum </em> resistant to antimalarial drugs. This study was undertaken to investigate the <em>in vivo </em> antiplasmodial effect of the aqueous stem bark extract of <em>Bombax buonopozense </em> in mice infected with chloroquine-sensitive <em>plasmodium berghei </em>NK65. The <em>in vivo </em> antiplasmodial effect against early infection and curative effect against established infection were studied. The extract at all doses (100, 200 and 400 mg/kg, <em>p.o </em>.) used, exhibited significant (P<0.05), dose-dependent activity against the parasite in suppressive and curative tests. These results show that the stem bark extract of <em>Bombax buonopozense </em> plant has significant antiplasmodial effect. The reduction in parasitemia levels in the two employed models suggest that a part of its antimalarial activity is mediated by direct plasmocidal effect on the parasite. </p> <p class="Anahtarkelime">Key words: Antimalaria, bombax buonopozense, medicinal plant, mice, plasmodium berghei </p> </div> <br />}, number={2}, publisher={Van Yüzüncü Yıl Üniversitesi}