TY  - JOUR
T1  - Psikososyal Stresin Kemik Sağlığına Etkileri
TT  - Effects of Psychosocial Stress on Bone Health
AU  - Emre, Mustafa
PY  - 2020
DA  - August
Y2  - 2020
DO  - 10.47141/geriatrik.727624
JF  - Geriatrik Bilimler Dergisi
JO  - GBD
PB  - Geriatrik Bilimler Derneği
WT  - DergiPark
SN  - 2636-8315
SP  - 66
EP  - 74
VL  - 3
IS  - 2
LA  - tr
AB  - Özet: Günümüzde, fiziksel stresin kemiğin yeniden şekillenmesini uyardığını ve karmaşık mekanotransdüksiyon mekanizmalarıyla kemik yapısını ve işlevini etkilediği gösterilmiştir. Son yapılan araştırmalar, fiziksel stresin yanı sıra psikososyal stresinde (zihinsel, davranışsal, duygusal) kemik biyolojisini etkilediği ve sonunda osteoporoza, kemik ağrılarına ve kemik kırık riskinin artmasına neden olduğu hipotezine zemin hazırlamıştır. Bu etkiler, muhtemelen hipotalamik-hipofiz-adrenal eksenindeki aktivitenin modülasyonu ile gerçekleştirildiği düşünülmektedir. İnsan ve deneysel hayvan çalışmalarında, psikososyal stresin insülin benzeri büyüme faktörleri, glukokortikoidler, katekolaminler, serotonin, GABA, beyin kaynaklı nörotrofik faktör, reseptör aktivatör nükleer kappa ligandı ve sitokinlerin (IL-1-6-11-17, TNFα) salınımında değişikliklere neden olduğu bildirilmiştir. Bu derlemede, psikososyal stresin kemiğin yapısal adaptasyonunda önemli bir oyuncu olduğuna dair mevcut bilgi durumu özetlenmiştir.Anahtar kelimeler: Stres, osteoporoz, kemik sağlığı
KW  - Stres
KW  - osteoporoz
KW  - kemik sağlığı
N2  - Summary: At the present time, it has been shown that physical stress stimulates the bone remodeling and affects the bone structure and function through complex mechanotransduction mechanisms. Recent research support the hypothesis that as well as physical stress, psychosocial stress (mental, behavioral, emotional) also affects the bone biology and eventually leads to osteoporosis, bone pain and increased risk of bone fracture. It has been considered that these effects originates from modulation of activity around the hypothalamic-pituitary-adrenal axis. In human and experimental animal studies, it has been reported that psychosocial stress brings about changes related to insulin-like growth factors, glucocorticoids, catecholamines, serotonin, GABA, brain-derived neurotrophic factor, receptor activator nuclear kappa ligand and  release in cytokines (IL-1-6-11 -17, TNFα). This review summarises the current state of knowledge that psychosocial stress has a crucial role in structural adaptation of bone.Keywords: Stress, osteoporosis, bone health
CR  - 1. Alexander G. Robling and Charles H. Turner. Mechanical Signaling for Bone Modeling and Remodeling. Crit Rev Eukaryot Gene Expr. 2009;19(4): 319–338.
CR  - 2. Klein-Nulend J, Bacabac RG, Bakker AD. Mechanical loading and how it affects bone cells: the role of the osteocyte cytoskeleton in maintaining our skeleton. Eur Cell Mater. 2012;24:278–91. doi:10.22203/eCM.v024a20
CR  - 3. Tümay Sözen, Lale Özışık, Nursel Çalık Başaran. An overview and management of osteoporosis. Eur J Rheumatol. 2017; 4: 46-56.
CR  - 4. Tan VPS, Macdonald HM, Kim S, et al. Influence of physical activity on bone strength in children and adolescents: a systematic review and narrative synthesis. J Bone Miner Res. 2014; 29:2161–81. doi:10.1002/jbmr.2254
CR  - 5. Maycas M, Esbrit P, Gortázar AR. Molecular mechanisms in bone mechanotransduction. Histol Histopathol. 2017;32(8):751-760. doi: 10.14670/HH-11-858.
CR  - 6. Bonewald LF. The amazing osteocyte. J Bone Miner Res.2011; 26:229–38. doi:10.1002/jbmr.320
CR  - 7. Baum A. Stress, intrusive imagery, and chronic distress. Health Psychol. 1990; 9:653–75. doi: 10.1037/0278-6133.9.6.653.
CR  - 8. Dickerson SS, Kemeny ME. Acute stressors and cortisol responses: a theo-retical integration and synthesis of laboratory research. Psychol Bull. 2004; 130:355–91. doi:10.1037/0033-2909.130.3.355
CR  - 9. Pia-Maria Wipper, Michael Recto, Gisela Kuhn et al. Stress and Alterations in Bones: An interdisciplinary Perspective. Frontiers in Endocrinology. 2017;8. doi: 10.3389/fendo.2017.00096.
CR  - 10. Levi L. Stress and Distress in Response to Psychosocial Stimuli: Laboratory and Real-Life Studies on Sympatho-Adrenomedullary and Related Reactions. Amsterdam: Elsevier (2016).
CR  - 11. Miller GE, Murphy MLM, Cashman R, et al. Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers. Brain Behav Immun. 2014; 41:191–9. doi: 10.1016/j.bbi.2014.05.016.
CR  - 12. Yang L, Zhao Y, Wang Y, et al. The effects of psychological stress on depression. Curr Neuropharmacol. 2015; 13:494–504. doi: 10.2174/1570159X1304150831150507
CR  - 13. Furlan PM, Ten Have T, Cary M, et al. The role of stress-induced cortisol in the relationship between depression and decreased bone mineral density. Biol Psychiatry. 2005; 57:911–7. doi:10.1016/j. biopsych.2004.12.033
CR  - 14. Julietta Ursula Schweiger, Ulrich Schweiger, Michael Hüppe, et al. Bone density and depressive disorder: a meta-analysis. Brain and Behavior. 2016; 6(8), e00489, doi: 10.1002/brb3.489
CR  - 15. Azuma K, Adachi Y, Hayashi H, et al. Chronic psychological stress as a risk factor of osteoporosis. J UOEH. 2015; 37:245–53. doi:10.7888/juoeh.37.245
CR  - 16. Williams LJ, Pasco JA, Jackson H, et al. Depression as a risk factor for fracture in women: a 10 year longitudinal study. J Affect Disord. 2016;192:34–40. doi:10.1016/j.jad.2015.11.048
17. Zhang ZD, Ren H, Shen GY, et al. Animal models for glucocorticoid-induced postmenopausal osteoporosis: An updated review. Biomed Pharmacother.2016; 84:438–46.
CR  - 18. Yirmiya R, Bab I. Major depression is a risk factor for low bone mineral density: a meta-analysis. Biol Psychiatry.2009; 66:423–32. doi:10.1016/j. biopsych.2009.03.016
CR  - 19. Willner P. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology.2005; 52:90–110. doi:10.1159/000087097.
CR  - 20. Neporada KS, Leont’eva FS, Tarasenko LM. Chronic stress impairs structural organization of organic matrix in bone tissue of rat periodontium. Bull Exp Biol Med.2003;135:543–4. doi:10.1023/A:1025464932135.
CR  - 21. Furuzawa M, Chen HY, Fujiwara S, et al. Chewing ameliorates chronic mild stress-induced bone loss in senescence-accelerated mouse (SAMP8), a murine model of senile osteoporosis. Exp Gerontol. 2014;55:12–8. doi:10.1016/j.exger.2014.03.003.
CR  - 22. Seferos N, Kotsiou A, Petsaros S, et al. Mandibular bone density and calcium content affected by different kind of stress in mice. J Musculoskelet Neuronal Interact (2010) 10:231–6.
CR  - 23. Toepfer P, Heim C, Entringer S, et al. Oxytocin path-ways in the intergenerational transmission of maternal early life stress. Neurosci Biobehav Rev. 2016; 73:293–308. doi:10.1016/j.neubiorev. 2016.12.026.
CR  - 24. Bowers ME, Yehuda R. Intergenerational transmission of stress in humans. Neuropsychopharmacology. 2016;41:232–44. doi:10.1038/npp.2015.247.
CR  - 25. Kelly RR, McDonald LT, Jensen NR, et al. Impacts of psychological stress on osteoporosis: clinical implications and treatment interactions. Front Psychiatr. 2019; 10:1-21. doi: 10.3389/fpsyt.2019.00200.
CR  - 26. Monolagas SC. Birth and death of bone cells. basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr. Rev. 2000;21, 115–117.
 
27. Cohen S, Janicki-Deverts D, Doyle WJ, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA. (2012) 109:5995–9. doi: 10.1073/pnas.1118355109
CR  - 28. El-Gabalawy R, Blaney C, Tsai J, et al. Physical health conditions associated with full and subthreshold PTSD in U.S. military veterans: results from the National Health and Resilience in Veterans Study. J Affect Disord. 2018;227:849–53. doi: 10.1016/j.jad.2017.11.058
CR  - 29. Paratz ED, Katz B. Ageing Holocaust survivors in Australia. Med J Aust.2011;194:194–7. doi: 10.5694/j.1326-5377.2011.tb03771.x
CR  - 30. Foertsch S, Haffner-Luntzer M, Kroner J, et al. Chronic psychosocial stress disturbs long-bone growth in adolescent mice Dis Model Mech. 2017; 10:1399–409. doi: 10.1242/dmm.030916
CR  - 31. Bottaccioli AG, Bottaccioli F, Minelli A. Stress and the psyche-brain-immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review. Ann N Y Acad Sci. 2018; 1437:31–42. doi: 10.1111/nyas.13728
CR  - 32. Chrousos GP. Stress, chronic inflammation, and emotional and physical well-being: concurrent effects and chronic sequelae. J Allergy Clin Immunol. 2000;106 (5 Suppl): S275–91. doi: 10.1067/mai.2000.110163
CR  - 33. Eastell R, O’Neill TW, Hofbauer LC, et al. Postmenopausal osteoporosis. Nat Rev Dis Primer. 2016; 2:16069. doi: 10.1038/nrdp.2016.69
CR  - 34. Pietschmann P, Mechtcheriakova D, Meshcheryakova A, et al. Immunology of osteoporosis: a mini-review. Gerontology. 2016; 62:128–37. doi: 10.1159/000431091
CR  - 35. Canalis E. Growth factor control of bone mass. J Cell Biochem. 2009;108:769–77. doi: 10.1002/jcb.22322
CR  - 36. Crane JL, Zhao L, Frye JS, et al. IGF-1 Signaling is essential for differentiation of mesenchymal stem cells for peak bone mass. Bone Res. 2013;1:186–94. doi: 10.4248/BR201302007
CR  - 37. Zegarra-Valdivia JA. Insulin-like growth factor type 1 and its relation with neuropsychiatric disorders. Medwave. 2017; 17:e(7031) doi: 10.5867/medwave.2017.07.7031
CR  - 38. Rosen CJ, Donahue LR, Hunter SJ. Insulin-like growth factors and bone: The osteoporosis connection. Proc Soc Exp Biol Med. 1994; 206(2): 83-102. doi: 10.3181/00379727-206-43726.
CR  - 39. Reijnders CM, Bravenboer N, Tromp AM, et al. Effect of mechanical loading on insulin-like growth factor-I gene expression in rat tibia. J Endocrinol. 2007;192:131–40. doi:10.1677/joe.1.06880.
CR  - 40. Wasserman E, Webster D, Kuhn G, et al. Differential load-regulated global gene expression in mouse trabecular osteo-cytes. Bone. 2013;53:14–23. doi:10.1016/j.bone.2012.11.017.
CR  - 41. Meakin LB, Todd H, Delisser PJ, et al. Parathyroid hormone’s enhancement of bones’ osteogenic response to loading is affected by ageing in a dose- and time-dependent manner. Bone. 2017; 98:59–67. doi:10.1016/j.bone.2017.02.009.
CR  - 42. Kulkarni RN, Bakker AD, Everts V, et al. Mechanical loading prevents the stimulating effect of IL-1beta on osteocyte-modulated osteo-clastogenesis. Biochem Biophys Res Commun. 2012; 420:11–6. doi:10.1016/j. bbrc.2012.02.099.
CR  - 43. Bot M, Milaneschi Y, Penninx BW, et al. Plasma insulin-like growth factor I levels are higher in depressive and anxiety disorders, but lower in antidepressant medication users. Psychoneuroendocrinology. 2016; 68:148– 55. doi: 10.1016/j.psyneuen.2016.02.028
CR  - 44. Deuschle M, Blum WF, Strasburger CJ, et al. Insulin-like growth factor-I (IGF-I) plasma concentrations are increased in depressed patients. Psychoneuroendocrinology.1997; 22:493–503.
CR  - 45. Santi A, Bot M, Aleman A, et al. Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man. Transl Psychiatry. 2018; 8:142. doi: 10.1038/s41398-058-0196-5
CR  - 46. Yasuhiro Tamura, Hiroko Okinaga, Hiroshi Takami. Glucocorticoid-induced osteoporosis; Biomedecine & Pharmacotherapy. 2004;58(9): 500-504.
CR  - 47. Miller GE, Murphy MLM, Cashman R, et al. Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers. Brain Behav Immun. 2014; 41:191–9. doi: 10.1016/j.bbi.2014.05.016
CR  - 48. Vega D, Maalouf NM, Sakhaee K. The role of receptor activator of nuclear factor-kappa B (RANK)/RANK ligand/osteoprotegerin: clinical implications. J Clin Endocrinol Metab.2007; 92:4514–21 doi: 10.1210/jc.2007-0646
CR  - 49. Briot K, Roux C. Glucocorticoid-induced osteoporosis. RMD Open. 2015; 1:e00(0014) doi: 10.1136/rmdopen-2014-000014
CR  - 50. Lopez-Alarcona C, Denicola A. Evaluating the antioxidant capacity of natural products: a review on chemical and cellular- based assays. Anal. Chim. Acta. 2013; 763: 1e10.
CR  - 51. Suzuki H, Hayakawa M, Kobayashi K, et al. H2O2-derived free radicals treated fibrinectin substratum reduces the bone nodule formation of rat calvarial osteoblast. Mech. Ageing Dev. 1997; 98: 113–125.
CR  - 52. Michel TM, Pülschen D, Thome J. The role of oxidative stress in depressive disorders. Curr Pharm Des. 2012; 18:5890–9. doi: 10.2174/138161212803523554
CR  - 53. Mao W, Zhu Z. Parthenolide inhibits hydrogen peroxide-induced osteoblast apoptosis. Mol Med Rep. 2018; 17:8369–76. doi: 10.3892/mmr.2018.8908
CR  - 54. Nazrun AS, Khairunnur A, Norliza M, et al. Effects of palm tocotrienols on oxidative stress and bone strength in ovariectomised rats. Med Health. 2008; 3:247–55.
CR  - 55. Sangkuhl K, Klein T, Altman R. Selective serotonin reuptake inhibitors pathway. Pharmacogenet Genomics. 2009; 19:907–9. doi: 10.1097/FPC.0b013e32833132cb.
CR  - 56. Wadhwa R, Kumar M, Talegaonkar S, et al. Serotonin reuptake inhibitors and bone health: A review of clinical studies and plausible mechanisms. Osteoporos Sarcopenia. 2017; 3:75–81. doi: 10.1016/j.afos.2017.05.002
CR  - 57. Dai SQ, Yu LP, Shi X, et al. Serotonin regulates osteoblast proliferation and function in vitro. Braz J Med Biol Res Rev Bras Pesqui Medicas E Biol. 2014; 47:759–65. doi: 10.1590/1414-431X20143565
CR  - 58. Hirai T, Kaneshige K, Kurosaki T, et al. Functional expression of 5-HT2A receptor in osteoblastic MC3T3-E1 cells. Biochem Biophys Res Commun. 2010; 396:278–82. doi: 10.1016/j.bbrc.2010.04.078
CR  - 59. Hodge JM, Wang Y, Berk M, et al. Selective serotonin reuptake inhibitors inhibit human osteoclast and osteoblast formation and function. Biol Psychiatry. 2013; 74:32–9. doi: 10.1016/j.biopsych.2012.11.003
CR  - 60. Dimitri P, Rosen C. The central nervous system and bone metabolism: an evolving story. Calcif Tissue Int. 2017; 100:476–85. doi: 10.1007/s00223-016-0179-6
CR  - 61. Ducy P, Karsenty G. The two faces of serotonin in bone biology. J Cell Biol. 2010; 191:7–13. doi: 10.1083/jcb.201006123
CR  - 62. Schildkraut JJ. The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry. 1965; 122:509–22. doi: 10.1176/ajp.122.5.509
CR  - 63. Vaessen T, Hernaus D, Myin-Germeys I, et al. T. The dopaminergic response to acute stress in health and psychopathology: a systematic review. Neurosci Biobehav Rev. 2015; 56:241–51. doi: 10.1016/j.neubiorev.2015.07.008
CR  - 64. Rodrigues W, Madeira M, da Silva T, et al. Low dose of propranolol down-modulates bone resorption by inhibiting inflammation and osteoclast differentiation. Br J Pharmacol. 2012; 165:2140–51. doi: 10.1111/j.1476-5381.2011.01686.x
CR  - 65. Kondo H, Togari A. Continuous treatment with a low-dose β- agonist reduces bone mass by increasing bone resorption without suppressing bone formation. Calcif Tissue Int.2011; 88:23–32. doi: 10.1007/s00223-010-9421-9
CR  - 66. Sani Ismaila Muhammad, Ismail Maznah, Rozi Mahmud, et al. Upregulation of genes related to bone formation by γ-amino butyric acid and γ-oryzanol in germinated brown rice is via the activation of GABAB-receptors and reduction of serum IL-6 in rats. Clinical Interventions in Aging. 2013:8; 1259–1271
 
67. Zheng SX, Vrindts Y, Lopez M et al. Increase in cytokine production (IL-1 β, IL-6, TNF-α but not IFN-γ, GM-CSF or LIF) by stimulated whole blood cells in postmenopausal osteoporosis. Maturitas. 1997; 26: 63–71.
CR  - 68. Sia YT, Parker TG, Liu P, et al. Improved postmyocardial infarction srvival with pobucol in rats: effects on left ventricular function, morphology, cardiac oxidative stress and cytokine expression. J. Am. Coll. Cardiol. 2002;39(1): 148–156.
CR  - 69. Afshari M, Larijani B, Abdollahi M et al. Ineffectiveness of allopurinol in reduction of oxidative stress in diabetic patients; A randomized, double-blind placebocontrolled clinical trial. Biomed. Pharmacother. 2004; 58: 546–550.
CR  - 70. Astaneie F, Larijani B, Abdollahi M et al. Alterations in anti-oxidant power and levels of epidermal growth factor and nitric oxide in blood and saliva of diabetic Type 1 patients. Arch. Med. Res.2005; 36: 376–381.
UR  - https://doi.org/10.47141/geriatrik.727624
L1  - https://dergipark.org.tr/tr/download/article-file/1268133
ER  -