TY - JOUR T1 - Acute leucoencephalopathy with restriction of diffusion-a case report AU - Vivek, Singh AU - Vaishali, Tomar AU - Alok, Kumar AU - Rajendra V., Phadke PY - 2014 DA - October JF - EASTERN JOURNAL OF MEDICINE PB - Van Yüzüncü Yıl Üniversitesi WT - DergiPark SN - 1301-0883 SP - 149 EP - 152 VL - 17 IS - 3 LA - en AB - Abstract. Acute white matter insult in a non traumatic, non ischemic background has been recently identified in certain clinical situations. Named toxic leukoencephalopathy, it may be caused by exposure to a wide variety of agents, including cranial irradiation, therapeutic agents, drugs of abuse, and environmental toxins. Extensive central white matter restriction of diffusion in the absence of significant T2 or Fluid-attenuated inversion recovery (FLAIR) abnormality is the imaging hallmark on Magnetic Resonance Imaging (MRI). Reversibility of the symptoms after the withdrawal of toxin has been shown in a few reports. We present one such case with reversal of changes on MRI and clinical improvement. Key words: ADEM, intramyelinic edema, PRES, toxic leukoencephalopathy KW - ADEM KW - intramyelinic edema KW - PRES KW - toxic leukoencephalopathy CR - Filley CM, Kleinschmidt-DeMasters BK. Toxic leukoencephalopathy. N Engl J Med 2001; 345: 425- 432. CR - McKinney AM, Kieffer SA, Paylor RT, et al. Acute toxic leukoencephalopathy: Potential for reversibility clinically and on MRI with diffusion-weighted and FLAIR imaging. AJR Am J Roentgenol 2009; 193: 192-206. CR - Schaefer PW, Grant PE, Gonzalez RG. Diffusion- weighted MR imaging of the brain. Radiology 2000; 217:331-345. CR - Nomura Y, Sakuma H, Takeda K, et al. Diffusional anisotropy of the human brain assessed with diffusion-weighted MR: relation with normal brain development and aging. AJNR Am J Neuroradiol 1994; 15: 231-238. CR - Wimberger DM, Roberts TP, Barkovich AJ, et al. Identification of “premyelination” by diffusion- weighted MRI. J Comput Assist Tomogr 1995; 19: 28- 33. CR - McKinney AM, Short J, Truwit CL, et al. Posterior reversible encephalopathy syndrome: Incidence of atypical regions of involvement and imaging findings. AJR Am J Roentgenol 2007; 189: 904-912. CR - Sivasubramanian S, Moorthy S, Sreekumar K, Kannan RR. Diffusion-weighted magnetic resonance imaging in acute reversible toxic leukoencephalopathy: A report of two cases. Indian J Radiol Imaging 2010; 20: 192-194. CR - Gallucci M, Limbucci N, Paonessa A, Caranci F. Reversible focal splenial lesions. Neuroradiology 2007; 49: 541-544. CR - Moritani T, Smoker WR, Sato Y, Numaguchi Y, Westesson PL. Diffusion-weighted imaging of acute excitotoxic brain injury. AJNR Am J Neuroradiol 2005; 26: 216-228. CR - Wani AA, Phadke R, Behari S, et al. Role of CR - diffusion-weighted MRG in predicting outcome in subarachnoid hemorrhage due to anterior communicating artery aneurysms. Turk Neurosurg 2008; 18: 10-16. UR - http://dergipark.org.tr/tr/pub/ejm/issue//72795 L1 - http://dergipark.org.tr/tr/download/article-file/62340 ER -