TY  - JOUR
T1  - MANUFACTURE OF SPHERICAL GRANULES OF ISOSORBIDE DINITRATE WITH MODIFIED RELEASE
TT  - MODİFİYE SALIMLI İSOSORBİT DİNİTRAT KÜRESEL GRANÜLLERİNİN ÜRETİMİ
AU  - Olıınykov, Dmytro
AU  - Kaplaushenko, Andrii
AU  - Trehub, Svetlana
AU  - Kovalyova, Katerina
PY  - 2020
DA  - September
Y2  - 2020
DO  - 10.33483/jfpau.736331
JF  - Journal of Faculty of Pharmacy of Ankara University
JO  - J. Fac. Pharm. Ankara
PB  - Ankara Üniversitesi
WT  - DergiPark
SN  - 1015-3918
SP  - 481
EP  - 493
VL  - 44
IS  - 3
LA  - en
AB  - Objective: This study was aimed to obtain spherical matrix pellets of isosorbide dinitrate with different dissolution kinetics to create a multidosage medicinal form with controlled release of the active substance.Material and Method: Spherical matrix granules were obtained by extrusion-spherinization and coated with different amounts of polymer shell. Dissolution profiles of the obtained spheroids were compared with reference drug tablets.Result and Discussion: The results showed that the combination of spherical granules provides an isosorbide dinitrate release profile similar to the dissolution of Cardicet Retard tablets. The target dissolution profile is achieved using a combination of uncoated spherical granules and spheroids with a 10% film coating. The similarity coefficient (f2) is 73.6.
KW  - Isosorbide dinitrate
KW  - release profile
KW  - spherical matrix pellets
N2  - Amaç: Bu çalışma, etkin maddenin kontrollü salımını yapan çok dozlu bir tıbbi form oluşturmak için farklı çözünme kinetiklerine sahip izosorbit dinitratın küresel matris pelletlerini elde etmeyi amaçlamıştır.Gereç ve Yöntem: Küresel matris granüller ekstrüder-sferonizer yöntemi ile elde edilmiş ve farklı miktarlarda polimer kabuk ile kaplanmıştır. Elde edilen kürelerin çözünme profilleri, referans ilaç tabletleri ile karşılaştırılmıştır.Sonuç ve Tartışma: Sonuçlar, küresel granüllerin kombinasyonunun, Cardicet Retard tabletlerinin çözünmesine benzer bir izosorbit dinitrat salım profili sağladığını göstermiştir. Hedef çözünme profili, kaplanmamış küresel granüller ve % 10'luk film kaplı kürelerin bir kombinasyonu kullanılarak elde edilmiştir. Benzerlik katsayısı (f2) 73.6'dır.
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UR  - https://doi.org/10.33483/jfpau.736331
L1  - http://dergipark.org.tr/tr/download/article-file/1100242
ER  -