TY  - JOUR
T1  - Molecular Pathways of Prostate Carcinoma
TT  - Prostat Karsinomunun Moleküler Yolakları
AU  - Bayramoğlu, Zeynep
AU  - Ünal, Betül
PY  - 2020
DA  - December
Y2  - 2020
DO  - 10.17944/mkutfd.755075
JF  - The Medical Journal of Mustafa Kemal University
JO  - mkutfd
PB  - Hatay Mustafa Kemal Üniversitesi
WT  - DergiPark
SN  - 2149-3103
SP  - 118
EP  - 123
VL  - 11
IS  - 41
LA  - en
AB  - Prostate cancer is one of the most common types of cancer with rapidly growing incidence rates in the world. The incidence and mortality rates of prostate cancer are widely variable in different populations. The prostate cancer includes multiple genetic modifications such as deletion in specific genome sequences of tumor-suppressor genes and alterations in specific chromosomal sites associated with oncogene activation. It is difficult to determine whether the hereditary changes leading to prostate cancer are associated with one or more specific genetic features. Prostate carcinogenesis is complex and has not been fully explained. If we can better understand prostate carcinogenesis, we can also find targeted therapy. Therefore, we talked about the major genetic and epigenetic changes involved in prostate carcinoma.
KW  - prostate carcinoma
KW  - molecular pathways
KW  - treatment
KW  - epigenetic
N2  - Prostat kanseri, dünyada hızla artan insidans oranlarına sahip en yaygın kanser türlerinden biridir. Prostat kanseri insidansı ve mortalite oranları farklı popülasyonlarda büyük ölçüde değişkendir. Prostat kanseri, tümör baskılayıcı genlerin spesifik genom sekanslarında delesyon ve onkogen aktivasyonu ile ilişkili spesifik kromozomal bölgelerdeki değişiklikler gibi çoklu genetik modifikasyonları içerir. Prostat kanseri yol açan kalıtsal değişikliklerin bir veya daha fazla spesifik genetik özellik ile ilişkili olup olmadığını belirlemek zordur. Prostat karsinogenezi çok karmaşık olup hala mekanizmaları olarak açıklanmamıştır. Eğer prostat karsinogenezini daha iyi anlayabilirsek bu hastalar için hedefe yönelik tedavi de bulabiliriz. Bu nedenle biz burada prostat karsinomunda yer alan büyük genetik ve epigenetik değişikliklerden bahsetmek istedik.
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UR  - https://doi.org/10.17944/mkutfd.755075
L1  - https://dergipark.org.tr/tr/download/article-file/1158801
ER  -