@article{article_756424, title={Assessment of Mean Platelet Volume in Acromegaly And Its Relation With The Treatment}, journal={Harran Üniversitesi Tıp Fakültesi Dergisi}, volume={17}, pages={355–359}, year={2020}, author={Akyay, Özlem Zeynep and Selek, Alev and Batman, Adnan and Çetinaslan, Berrin and Cantürk, Zeynep and Tarkun, İlhan}, keywords={Acromegaly, Atherosclerosis, İnflammation, Mean Platelet Volume}, abstract={<p>Background: Mean platelet volume (MPV) is an independent risk factor of atherosclerosis and thrombotic events. We aimed this study evaluates the levels of MPV in acromegalic patients and its relationship with treatment. <br />Materials and Methods: In this study, we examined the levels of MPV in acromegalic patients before and after treatment and also at two years of remission. The results were also compared with a control group. A total of 80 patients treated at our clinic with the diagnosis of acromegaly age- and gender-matched nonacromegalic controls were reviewed retrospectively. Preoperative and postoperative MPV values as well as MPV values two years after controlling disease in patients with medical treatment were compared. <br />Results: MPV values were significantly higher in both the diabetic and non-diabetic acromegaly patients compared with the control subjects (p=0,02). Postoperative MPV values were significantly reduced compared to preoperative values in patients cured after surgery (p=0,001). Patients who achieved disease control with medical therapy after failure of surgical intervention demonstrated MPV values similar to those reported in patients cured with, even after two years from surgery (p=0,001). <br />Conclusions: Our findings suggested that MPV would be a beneficial marker for atherosclerosis and inflammation in patients with acromegaly. <br /> </p>}, number={3}, publisher={Harran Üniversitesi}