TY  - JOUR
T1  - Correlation of (18F) FDG PET/CT Parameters with Haematological Parameters in Esophageal Cancers and the Effect of These Parameters on Survival
TT  - Correlation of (18F) FDG PET/CT Parameters with Haematological Parameters in Esophageal Cancers and the Effect of These Parameters on Survival
AU  - Can, Canan
PY  - 2020
DA  - September
DO  - 10.5798/dicletip.799655
JF  - Dicle Medical Journal
JO  - diclemedj
PB  - Dicle Üniversitesi
WT  - DergiPark
SN  - 1300-2945
SP  - 556
EP  - 567
VL  - 47
IS  - 3
LA  - en
AB  - Objective: In the present study, we aimed to investigate the relationship between metabolic (SUVmax) and volume-based (18F)FDG PET/CT parameters (metabolic tumour volume (MTV) and total lesion glycolysis (TLG)) and haematological parameters (neutrophil, lymphocyte, platelet,mean platelet volume(MPV) , neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (TLR)) with survival, and whether haematological parameters are correlated with metabolic and volume-based PET parameters.Method: We included a total of 55 patients who underwent (18F)FDG PET/CT in our nuclear medicine clinic between January 2017 and December 2018 with a diagnosis of esophageal squamous cell carcinoma, had no distant metastasis, either had or did not have regional lymph node metastasis, whose imaging and laboratory data could be retrospectively accessed, who did not undergo an operation before imaging, did not receive chemo-radiotherapy.Results: In multivariate regression analysis, we found esophageal MTV (OR 2.6; 95% CI 1.04–6.57, p: 0.041) and esophageal TLG (OR 2.7; 95% CI 1.2–6.2, p: 0.022) values to be independent variables in terms of survival. While we observed a negative correlation between PLR and esophageal MTV and TLG (p values were respectively p: 0.021, p: 0.03), we observed a positive correlation between lymphocyte counts and esophageal MTV and TLG (p values were p: 0.004, p: 0.001, respectively). We detected a positive correlation between the size and SUVmax of lymph node metastasis, on the one hand, and both neutrophil counts and NLR on the other.Conclusion: We determined MTV and TLG values, which are volume-based metabolic PET parameters, to be independent prognostic factors for survival. MTV and TLG had a negative correlation with PLR and a positive correlation with lymphocyte counts.
KW  - Survival
KW  - Volume-based PET/CT parameters
KW  - Esophageal cancer
KW  - neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (TLR).
CR  - 1.Bray F, Ferlay J, Soerjomataram I, et al. GlobalCancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2018; 68: 394–424.
CR  - 2.Blot WJ TR. Cancer Epidemiology and Prevention.4th ed. Thun MJ, Linet MS, Cerhan JR, Haiman CA SD(eds). New york, Oxford University Press, 2018;579–92.
CR  - 3.Baquet CR, Commiskey P, Mack K, et al.Esophageal cancer epidemiology in blacks andwhites: Racial and gender disparities in incidence,mortality, survival rates and histology. J Natl MedAssoc. 2005; 97: 1471–8.
UR  - https://doi.org/10.5798/dicletip.799655
L1  - https://dergipark.org.tr/tr/download/article-file/1308370
ER  -