TY - JOUR T1 - Çocuklarda Subkutan İmmünglobülin Kullanımı TT - Subcutaneous Immunoglobulin Use in Children AU - Acar, Manolya AU - Somer, Ayper PY - 2017 DA - October DO - 10.5222/j.child.2017.146 JF - Çocuk Dergisi PB - İstanbul Üniversitesi WT - DergiPark SN - 1308-8491 SP - 146 EP - 150 VL - 17 IS - 4 LA - tr AB - İnsan plazma kaynaklı immünglobülinler başta primer immün yetersizlik hastalıkları olmak üzere pek çok hastalı- ğın tedavi seçenekleri arasında yer almaktadır. İmmünglobülin preparatları; intravenöz IV , subkutan SC ya da intramüsküler IM yolla verilebilir. Son yıllar- da subkutan immünglobülin SIG uygulaması, hasta konfo- runun daha yüksek, maliyetinin ve yan etki insidansının daha düşük olması nedeniyle tercih edilmektedir. Bu yazıda çocuk hastalarda SIG kullanımı ile ilgili güncel bilgiler özetlenmiştir KW - Subkutan immünglobülin KW - çocuk KW - tedavi N2 - Human plasma derived immunoglobulin products have been considered among treatment options for many of the disor- ders, particularly primary immune deficiencies. Immunoglobulins can be administered either intravenous IV , subcutaneous SC or intramuscular IM route. In recent years, SCIG use has been preferred increasingly because of higher patient comfort, with decreased systemic side effects and costs. Up-to-date information regarding SCIG use in pediatric patients is being summarized in this review CR - Bruton oc. Agammaglobulinemia. Pediatrics 1952;9:722-8. CR - Jolles S. Subcutaneous and intramuscular immune globulin therapy. www.uptodate.com. CR - Janeway CA, Apt l, Gitlin D. Agammaglobulinemia. Trans Assoc Am Physicians 1953;66:200-2. CR - Gitlin D, Janeway CA. Agammaglobulinemia: conge- nital, acquired and transient forms. 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Use of subcutaneous immunoglobulin in primary immune deficiencies. Turk Pediatri Ars 2016;51:8-14. CR - https://doi.org/10.5152/TurkPediatriArs.2016.3058 CR - Abolhassani H, Sadaghiani MS, Aghamohammadi A, Ochs HD, Rezaei n. Home-based subcutaneous immunoglobulin versus hospital-based intravenous immunoglobulin in treatment of primary antibody defi- ciencies: systematic review and meta-analysis. J Clin Immunol 2012;32:1180-92. CR - https://doi.org/10.1007/s10875-012-9720-1 CR - Bonilla FA, Duff C. Subcutaneous Immunoglobulin Replacement. Immune Deficiency Foundation: Clinical Focus 2015;16:1-16. UR - https://doi.org/10.5222/j.child.2017.146 L1 - https://dergipark.org.tr/tr/download/article-file/1309351 ER -