TY - JOUR T1 - Çocuklarda Trombositopeniye Yaklaşım TT - Approach to Thrombocytophenia in Children AU - Aydoğdu, Selime AU - Karaman, Serap AU - Karakaş, Zeynep PY - 2016 DA - July DO - 10.5222/j.child.2016.067 JF - Çocuk Dergisi PB - İstanbul Üniversitesi WT - DergiPark SN - 1308-8491 SP - 67 EP - 73 VL - 16 IS - 2 LA - tr AB - Trombositler primer hemostazda görevli ana elemanlardır. Trombosit sayısının 150.000/mm3’den düşük olmasına trombositopeni denir. Trombositopenik hastaya yaklaşımda detaylı öykü alınması, tam fizik muayene yapılması ve labo- ratuar değerlendirmede periferik yaymanın kesinlikle ince- lenmsi gerekir. Trombositlerin sayı ve morfolojisi, küme oluşturması, diğer kan elemanlarının sayısal ve morfolojik değerlendirlmesi için periferik yayma tanısal yaklaşımda altın standarttır KW - Çocuk KW - trombositopeni KW - periferik yayma N2 - Platelets are the key elements that are responsible for pri- mary hemostasis. When absolute number of platelets in peripheral blood is less than 150000/mm3, it is called thrombocytopenia. Detailed anamnesis, complete physical examination and a laboratory evaluation including perip- heral blood smear are vital when approaching to throm- bocytopenic patients. Peripheral blood smear is the gold standard diagnostic approach for quantitative, and morp- hological evaluation of number, morphology and clustering of platelets and other blood elements as well CR - Beyan C, nevruz o. Kanama ve tromboz (Çeviri). Harrison İç Hastalıkları Prensipleri (Çeviri). Çeviri Editörü: Yahya Sağlıker. Cilt 1, 15. Edisyon, Nobel Tıp Kitabevleri, 2004: 354-60. CR - McGuinn C, Bussel JB. Disorders of platelets. Lanzkowsky’s manual of pediatric hematology and oncology. Sixth Edition 2016;239-278. CR - https://doi.org/10.1016/B978-0-12-801368-7.00014-4 CR - Kılınç Y. Trombositopenilerde tanısal yaklaşım (Algoritma). Türk Pediatrik Hematoloji Derneği, TPHD Eğitim Serisi-IV, Trombosit Hastalıkları. Galenos Yayıncılık, 2017;31-34. CR - Liu Y, Chen S, Sun Y, Lin Q, Liao X, Zhang J, et al. Clinical characteristics of immune thrombocytopenia associated with autoimmune disease: A retrospective study. Medicine (Baltimore) 2016;95:5565. CR - https://doi.org/10.1097/MD.0000000000005565 CR - Choi SI, mcClure Pd. Idiopathic thrombocytopenic purpura in childhood. Can Med Assoc J 1967;97:562- 568. CR - Franchini m. The platelet-function analyzer (PFA– 100®) for evaluating primary hemostasis. Hematology 2005;10:177-81. CR - https://doi.org/10.1080/10245330400026097 CR - drachman JG. Inherited thrombocytopenia: when a low platelet count does not mean ITP. Blood 2004;103:390-8. CR - https://doi.org/10.1182/blood-2003-05-1742 CR - Wilon DB. Acquired platelet disorders. In Nathan and Oski’s Hematology of infancy and childhood. 7th edition. 2009;1553-1590 . CR - Albert mH, noterangelo Ld, occhs Hd. Clinical spectrum, pathophysiology and treatment of theWiskott- Aldrich syndrome. Curr Opin Hematol 2011;18:42-8. CR - https://doi.org/10.1097/MOH.0b013e32834114bc CR - Evans rS, Takahashi K, duane rT. Primary throm- bocytopenic purpura and acquired haemolytic anemia. Arch Int Med 1951;87:48-65. CR - https://doi.org/10.1001/archinte.1951.03810010058005 CR - Aul C, Giagounidis A, et al. Evaluating the prognosis of patients with myelodysplastic syndromes. Review article. Ann Hematol 2002;81:485-97. CR - https://doi.org/10.1007/s00277-002-0530-z CR - nakao S, Ishiyama K. Hypomegakaryocytic throm- bocytopenia and increased number of PNH-phenotype cells-an emerging subgroup of myelodysplastic syndro- me showing frequent response to immunosuppression- Response to Refferr to Rafferty&Leach. Correspon- dence. Br J Haematol 2017; 14755. CR - https://doi.org/10.1111/bjh.14755 CR - Bussel JB. Alloimmune thrombocytopenia in the fetus and newborn. Semin Thromb Hemos 2001;27:245-52. CR - https://doi.org/10.1055/s-2001-15254 CR - roberts I, Stanworth S, murray nA. Thrombocyto- phenia in neonate. Blood Rev 2008;22:173-86. CR - https://doi.org/10.1016/j.blre.2008.03.004 CR - WongW, Glader B. Approach to the newborn who has thrombocytophenia. Neo Reviews 2004;5:444-9. CR - https://doi.org/10.1542/neo.5-10-e444 CR - murray nA, Howarth LJ, mcCloy mP, Letsky EA, roberts IA. Platelet transfusion in the management of severe thrombocytophenia in neonatal intensive care unit patients. Transfus Med 2002;12:35-41. CR - https://doi.org/10.1046/j.1365-3148.2002.00343.x CR - Bussel JB, Zacharoulis S, Kramer K, mcFarland JG, Pauliny J, Kaplan C. Clinical and diagnostic comparison of neonatal alloımmune thrombocytophe- nia to non-immun cases of thromboctrophenia. Pediatr Blood Cancer 2005;45:176-83. CR - https://doi.org/10.1002/pbc.20282 CR - George r. Buchanan. Thrombocytopenia during child- hood: What the pediatrician needs to know? Pediatrics in Review 2005;26(11):401-9. CR - Audia S, rossato m, Santegoets K, Spijkers S, Wichers C, Bekker C, et al. Splenic TFH expansion partipipates in B-cell differentiation and antiplatelet antibody production during immune thrombocytophe- nia. Blood 2014;124:2858-86. CR - https://doi.org/10.1182/blood-2014-03-563445 CR - Cox K, Price V, Kahr WH. Inherited platelet disor- ders: a clinical approach to diagnosis and management. Expert Rev Hematol 2011;4:455-72. CR - Stasi r. How to approach thrombocytophenia. ASH Education Program Book 2012;191-197. UR - https://doi.org/10.5222/j.child.2016.067 L1 - https://dergipark.org.tr/tr/download/article-file/1321984 ER -